INT19408

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 37
Total Number 37
Disease Relevance 6.23
Pain Relevance 14.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c22)
Anatomy Link Frequency
PSP 2
neuronal 1
plasma 1
blood 1
hepatocytes 1
Cyp2c22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 30 100.00 Very High Very High Very High
Morphine 12 100.00 Very High Very High Very High
Paracetamol 258 99.84 Very High Very High Very High
sSRI 6 99.80 Very High Very High Very High
analgesia 7 99.62 Very High Very High Very High
Arthritis 13 99.46 Very High Very High Very High
fluoxetine 7 99.34 Very High Very High Very High
Potency 3 99.20 Very High Very High Very High
Bioavailability 4 98.36 Very High Very High Very High
Opioid 7 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sepsis 6 99.56 Very High Very High Very High
Arthritis 13 99.46 Very High Very High Very High
Stress 7 99.26 Very High Very High Very High
Death 49 98.20 Very High Very High Very High
Injury 20 96.92 Very High Very High Very High
Aging 2 96.56 Very High Very High Very High
Apoptosis 16 96.12 Very High Very High Very High
Pain 10 91.12 High High
Hypersensitivity 1 90.72 High High
Hepatotoxicity 22 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppression of acetaminophen conjugation and of conjugate elimination in the rat by metyrapone, a classical P-450 inhibitor.
Negative_regulation (inhibitor) of P-450 associated with paracetamol
1) Confidence 0.59 Published 1988 Journal Drug Metab. Dispos. Section Title Doc Link 2900724 Disease Relevance 0 Pain Relevance 0.78
In addition, following high doses of SKF-525A or PB, sufficient to induce a complete inactivation of cytochromes P-450, DTG still potentiated the NMDA response.
Negative_regulation (inactivation) of P-450
2) Confidence 0.49 Published 1993 Journal Synapse Section Abstract Doc Link 8427011 Disease Relevance 0 Pain Relevance 0.38
Furthermore, the locomotor-stimulant effects of cocaine in rodents are enhanced by fluoxetine and fluvoxamine, SSRIs known to inhibit cocaine-metabolizing cytochrome P450 enzymes, whereas citalopram, an SSRI that does not inhibit P450 enzymes, does not enhance cocaine's locomotor-stimulant effects.
Negative_regulation (inhibit) of P450 associated with ssri, fluoxetine and cocaine
3) Confidence 0.42 Published 2009 Journal Behav Pharmacol Section Abstract Doc Link 20195220 Disease Relevance 0 Pain Relevance 0.85
The swim stress-induced analgesia was significantly decreased in neonatal morphine-exposed rats on P29, but not on P49.
Negative_regulation (decreased) of P49 associated with stress, morphine and analgesia
4) Confidence 0.38 Published 2008 Journal Brain Res. Section Abstract Doc Link 18267316 Disease Relevance 0.99 Pain Relevance 2.19
The inhibition of cytochrome P-450-linked monooxygenase systems by FK-506 seemed to involve the direct inhibition of cytochromes P-450 because the NADPH-cytochrome c reductase and NADPH-ferricyanide reductase activities of NADPH-cytochrome P-450 reductase were not affected by the presence of 1 mM FK-506 at all.
Negative_regulation (inhibition) of cytochromes P-450
5) Confidence 0.38 Published 1997 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 9304807 Disease Relevance 0 Pain Relevance 0.08
Furthermore, the locomotor-stimulant effects of cocaine in rodents are enhanced by fluoxetine and fluvoxamine, SSRIs known to inhibit cocaine-metabolizing cytochrome P450 enzymes, whereas citalopram, an SSRI that does not inhibit P450 enzymes, does not enhance cocaine's locomotor-stimulant effects.
Negative_regulation (inhibit) of P450 associated with ssri, fluoxetine and cocaine
6) Confidence 0.36 Published 2009 Journal Behav Pharmacol Section Abstract Doc Link 20195220 Disease Relevance 0 Pain Relevance 0.83
Hepatic cytochrome P-450 levels were unchanged but cytochrome P-450 mediated p-nitroanisole demethylation was reduced by disulfiram pretreatment.
Negative_regulation (reduced) of P-450
7) Confidence 0.36 Published 1988 Journal Pharmacol. Toxicol. Section Abstract Doc Link 3413028 Disease Relevance 0.40 Pain Relevance 0.50
Therefore, inhibition of P-450 activity seems to be more important for reducing the generation of the reactive metabolites of acetaminophen than hepatic blood flow decrease.
Negative_regulation (inhibition) of P-450 in blood associated with paracetamol
8) Confidence 0.35 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3773340 Disease Relevance 0.47 Pain Relevance 0.78
Diether ether is known to be metabolized by cytochrome P450 IIE1 which is induced by fasting and by diethyl ether, and is possibly involved in the observed radical production, lipid peroxidation, and loss of cytochromes P-450.
Negative_regulation (loss) of cytochromes P-450
9) Confidence 0.34 Published 1991 Journal Xenobiotica Section Abstract Doc Link 2058176 Disease Relevance 0.07 Pain Relevance 0
Total cytochromes P-450 of liver and kidney of rats were decreased to 25-30% of control values after 20 h fasting and 4 min of ether anaesthesia, but were restored to normal levels 2 h later.
Negative_regulation (decreased) of cytochromes P-450 in kidney
10) Confidence 0.29 Published 1991 Journal Xenobiotica Section Abstract Doc Link 2058176 Disease Relevance 0.07 Pain Relevance 0
A 30% decrease in cytochromes P-450 induced by cobalt chloride failed to provide protection against APAP lethality.
Negative_regulation (decrease) of cytochromes P-450 associated with paracetamol
11) Confidence 0.29 Published 1995 Journal Hepatology Section Abstract Doc Link 7843722 Disease Relevance 0.36 Pain Relevance 1.06
Because TA caused a 23% decrease of hepatic microsomal cytochromes P-450, the possibility that TA protection may be caused by decreased bioactivation of APAP was examined.
Negative_regulation (decrease) of cytochromes P-450 associated with paracetamol
12) Confidence 0.25 Published 1995 Journal Hepatology Section Abstract Doc Link 7843722 Disease Relevance 0.34 Pain Relevance 0.94
The inhibition of cytochrome P-450-linked monooxygenase systems by FK-506 seemed to involve the direct inhibition of cytochromes P-450 because the NADPH-cytochrome c reductase and NADPH-ferricyanide reductase activities of NADPH-cytochrome P-450 reductase were not affected by the presence of 1 mM FK-506 at all.
Negative_regulation (inhibition) of P-450
13) Confidence 0.24 Published 1997 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 9304807 Disease Relevance 0 Pain Relevance 0.09
Intraperitoneal administration of 9-hydroxyellipticine, a specific cytochrome P-448 inhibitor, inhibited 3-methylcholanthrene-induced cytochrome P-448 activity (ethoxyresorufin O-deethylase, biphenyl 2-hydroxylase) and formation of the safrole carbene ligand complex with this cytochrome, but did not inhibit phenobarbital-induced cytochrome P-450 activity (ethyl-morphine N-demethylase) or formation of the safrole carbene ligand complex with this cytochrome.
Negative_regulation (inhibit) of P-450 associated with morphine
14) Confidence 0.17 Published 1982 Journal Chem. Biol. Interact. Section Abstract Doc Link 7151231 Disease Relevance 0 Pain Relevance 0.10
To eliminate concomitant metabolism, cells were pretreated with the irreversible P450 inhibitor, aminobenzotriazole.
Negative_regulation (inhibitor) of P450
15) Confidence 0.16 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17470525 Disease Relevance 0 Pain Relevance 0.30
Effects of caffeine and theophylline on acetaminophen pharmacokinetics: P450 inhibition and activation.
Negative_regulation (inhibition) of P450 associated with paracetamol
16) Confidence 0.15 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8613932 Disease Relevance 0 Pain Relevance 0.51
Adjuvant-induced arthritis resulted in a significant reduction in hepatic cytochrome P-450 levels and in p-nitrophenol glucuronidation (5.65 +/- 0.40 versus 2.58 +/- 0.27 micromol.min/mg protein in control and arthritic rats, respectively, mean +/- S.E.M.).
Negative_regulation (reduction) of P-450 associated with arthritis
17) Confidence 0.13 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 9884306 Disease Relevance 0.64 Pain Relevance 0.32
Cytochrome P-450-dependent formation of reactive oxygen radicals: isozyme-specific inhibition of P-450-mediated reduction of oxygen and carbon tetrachloride.
Negative_regulation (reduction) of P-450-mediated
18) Confidence 0.11 Published 1990 Journal Xenobiotica Section Title Doc Link 2122605 Disease Relevance 0 Pain Relevance 0.09
Total cytochromes P-450 of liver and kidney of rats were decreased to 25-30% of control values after 20 h fasting and 4 min of ether anaesthesia, but were restored to normal levels 2 h later.
Negative_regulation (decreased) of cytochromes P-450 in liver
19) Confidence 0.10 Published 1991 Journal Xenobiotica Section Abstract Doc Link 2058176 Disease Relevance 0.07 Pain Relevance 0
The aim of this study was to examine the effect of oral administration of diallyl sulfide--a cytochrome P450 2E1 inhibitor and cimetidine--a cytochrome P450 2C6 and 2C11 inhibitor on rat serum concentration of phenacetin and its metabolite acetaminophen.
Negative_regulation (inhibitor) of P450 associated with paracetamol
20) Confidence 0.09 Published 2002 Journal Acta Biochim. Pol. Section Abstract Doc Link 12136947 Disease Relevance 0 Pain Relevance 0.25

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