INT19409

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 2.58
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cyp1a1) mitochondrion (Cyp1a1) oxidoreductase activity (Cyp1a1)
aging (Cyp1a1) endoplasmic reticulum (Cyp1a1) enzyme binding (Cyp1a1)
Anatomy Link Frequency
liver 1
Cyp1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
endometriosis 4 100.00 Very High Very High Very High
Chronic pancreatitis 2 99.84 Very High Very High Very High
carbamazepine 1 99.36 Very High Very High Very High
anesthesia 2 97.04 Very High Very High Very High
halothane 2 95.96 Very High Very High Very High
Potency 3 95.86 Very High Very High Very High
ketamine 3 94.40 High High
Lamotrigine 1 94.28 High High
Gabapentin 1 93.64 High High
lidocaine 6 90.12 High High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 4 100.00 Very High Very High Very High
Pancreatitis 7 99.84 Very High Very High Very High
Generalized Epilepsy 1 99.70 Very High Very High Very High
Alcoholic Liver Cirrhosis 2 99.44 Very High Very High Very High
Epilepsy 11 98.52 Very High Very High Very High
Cirrhosis 7 90.04 High High
Syndrome 3 88.40 High High
Disease 4 75.08 Quite High
Low Back Pain 2 75.00 Quite High
Injury 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This difference in potency, which is most likely attributable to the change in the chemical composition in the aliphatic chain among the compounds, suggests that these compounds may be useful probes for studying the mechanism of the interaction with the active site of CYP1A1.
CYP1A1 Binding (interaction) of associated with potency
1) Confidence 0.48 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8689940 Disease Relevance 0 Pain Relevance 0.72
Investigations of the binding of APAP to CYP1A1 and CYP2B1 were carried out to assess the possibility that different preferred orientations of APAP in the active sites of these isoforms may, in part, by responsible for their different product selectivities.
CYP1A1 Binding (binding) of
2) Confidence 0.45 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 8145237 Disease Relevance 0 Pain Relevance 0.23
Two isotopically substituted analogs of APAP, [2,3',5'-13C3]-4'-hydroxyacetanilide and 4'-hydroxyacet-[15N]-anilide, were synthesized, and their binding to purified CYP1A1 and CYP2B1 was examined by NMR spectroscopy.
CYP1A1 Binding (binding) of
3) Confidence 0.45 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 8145237 Disease Relevance 0 Pain Relevance 0.13
OBJECTIVES: To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan.
CYP1A1 Binding (associations) of
4) Confidence 0.37 Published 2003 Journal Immunol. Lett. Section Abstract Doc Link 12880680 Disease Relevance 0.07 Pain Relevance 0.07
Theophylline was used as a probe for CYP1A activity, phenobarbital for CYP2B/2C, flecainide for CYP2D1, and ethosuximide for CYP3A activity.
CYP1A Binding (activity) of
5) Confidence 0.33 Published 1995 Journal Pharmacology Section Abstract Doc Link 7746831 Disease Relevance 0 Pain Relevance 0.26
OBJECTIVES: To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan.
cytochrome p450 1A1 Binding (associations) of
6) Confidence 0.32 Published 2003 Journal Immunol. Lett. Section Abstract Doc Link 12880680 Disease Relevance 0.07 Pain Relevance 0.07
Diether ether is known to be metabolized by cytochrome P450 IIE1 which is induced by fasting and by diethyl ether, and is possibly involved in the observed radical production, lipid peroxidation, and loss of cytochromes P-450.
cytochrome P450 IIE1 Binding (metabolized) of
7) Confidence 0.30 Published 1991 Journal Xenobiotica Section Abstract Doc Link 2058176 Disease Relevance 0.07 Pain Relevance 0
Neither the CYP1A1 nor CYP17 genes had any significant association with either of the two diseases.
CYP1A1 Binding (association) of
8) Confidence 0.18 Published 2006 Journal Hum. Reprod. Section Body Doc Link 16527884 Disease Relevance 0.12 Pain Relevance 0
OBJECTIVE: To investigate whether genetic polymorphisms of CYP1A1, GSTM1, and GSTT1 are associated with endometriosis.
CYP1A1 Binding (associated) of associated with endometriosis
9) Confidence 0.15 Published 2001 Journal Fertil. Steril. Section Abstract Doc Link 11730751 Disease Relevance 0.17 Pain Relevance 0.09
In conclusion, our data indicate an association between occurrence of the Val/Val GSTP1 genotype and chronic pancreatitis and an association between the m2/m2 CYP1A1 genotype and alcoholic liver cirrhosis.
CYP1A1 Binding (association) of in liver associated with alcoholic liver cirrhosis and chronic pancreatitis
10) Confidence 0.09 Published 2004 Journal Mutagenesis Section Abstract Doc Link 15215328 Disease Relevance 1.26 Pain Relevance 0.16
CONCLUSION: CYP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.


CYP1A1 MspI Binding (association) of
11) Confidence 0.05 Published 2007 Journal Reprod. Toxicol. Section Body Doc Link 17566695 Disease Relevance 0 Pain Relevance 0
Women without epilepsy (23 controls) and women with localization-related epilepsy (LRE, n = 59) or idiopathic (primary) generalized epilepsy (IGE, n = 35) receiving either a cytochrome P450 enzyme (cP450) inducing AED (carbamazepine, phenytoin, and phenobarbital), a cP450 inhibiting AED (valproate), or an AED that does not alter cP450 enzymes (lamotrigine and gabapentin) in monotherapy for 6 months or more were followed for three menstrual cycles.
cP450 Binding (receiving) of associated with epilepsy, lamotrigine, generalized epilepsy, gabapentin and carbamazepine
12) Confidence 0.01 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 12447923 Disease Relevance 0.79 Pain Relevance 0.24

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