INT1941

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1977
Last Reported 2009
Negated 2
Speculated 2
Reported most in Body
Documents 36
Total Number 38
Disease Relevance 5.92
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSTPIP1) signal transduction (PSTPIP1) oxidoreductase activity (PSTPIP1)
cell adhesion (PSTPIP1) cytoskeleton (PSTPIP1) cytoplasm (PSTPIP1)
Anatomy Link Frequency
filaments 6
SH3 5
tubules 1
mononuclear cells 1
PSTPIP1 (Homo sapiens)
PSTPIP1 - W232A (1)
Pain Link Frequency Relevance Heat
Inflammation 339 99.24 Very High Very High Very High
Multiple sclerosis 65 98.56 Very High Very High Very High
Arthritis 70 90.76 High High
Fibrositis 97 90.20 High High
Central nervous system 4 89.32 High High
palliative 1 85.04 High High
chemokine 17 83.04 Quite High
cytokine 16 62.80 Quite High
Stimulus evoked pain 1 42.84 Quite Low
COX2 1 38.24 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 322 99.72 Very High Very High Very High
Disease 372 99.50 Very High Very High Very High
INFLAMMATION 341 99.24 Very High Very High Very High
Fever 388 99.20 Very High Very High Very High
Cancer 5 98.70 Very High Very High Very High
Multiple Sclerosis 69 98.56 Very High Very High Very High
Familial Mediterranean Fever 25 95.76 Very High Very High Very High
Acne 70 92.04 High High
Pyoderma Gangrenosum 70 91.64 High High
Arthritis 70 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, our studies show clearly that the SH3 domain of PSTPIP1 is not required for pyrin binding nor is it necessary for pyrin-mediated reticularization of PSTPIP1 filaments.
PSTPIP1 Binding (binding) of in filaments
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.05 Pain Relevance 0.03
The results of these analyses suggest a revised model of pyrin/PSTPIP interaction in the context of inflammatory disease.


PSTPIP Binding (interaction) of associated with inflammation and disease
2) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.20 Pain Relevance 0.05
We also examine the pyrin/PSTPIP1 interaction and show that contrary to earlier predictions [5], the PSTPIP1 SH3 domain is not required for its interaction with pyrin.
PSTPIP1 Spec (examine) Binding (interaction) of in SH3
3) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.21 Pain Relevance 0
We next examined smaller fragments of the pyrin molecule to determine which regions are required for PSTPIP1 binding and filament redistribution.
PSTPIP1 Binding (binding) of in filament
4) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
The model also suggests that the coherent convex binding surface would likely interact with both pyrin and the PEST phosphatases, since these PSTPIP1 mutations have been shown to reduce binding affinity for PEST phosphatases and increase affinity for pyrin (Shoham, 2005).


PEST Binding (affinity) of
5) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.07 Pain Relevance 0
PSTPIP1 filament formation in transfected cells: lack of requirement for the SH3 domain and effect of PAPA-associated mutations
PSTPIP1 Binding (formation) of in SH3
6) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
Finally, we directly test the binding relationships between PSTPIP1, pyrin, and the pyrin-binding protein ASC.
PSTPIP1 Binding (binding) of
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.38 Pain Relevance 0.04
PSTPIP1 filaments are lipid membrane associated
PSTPIP1 Binding (associated) of in filaments
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.09 Pain Relevance 0
Thus, the SH3 domain is apparently dispensable for the interaction between pyrin and PSTPIP1.
PSTPIP1 Binding (interaction) of in SH3
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
PSTPIP1 has previously been linked to the actin cytoskeleton [13], and we report an additional requirement for the tubulin cytoskeleton in generation of PSTPIP1 filamentous structure.
PSTPIP1 Binding (linked) of
10) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
Pyrin exons 2–4 produced a protein capable of aligning with PSTPIP1 filaments, but the PSTPIP1 filament network was not reticularized (Figure 5E–F).
PSTPIP1 Binding (aligning) of in filament
11) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.05 Pain Relevance 0
These data suggest that the PSTPIP1 pattern may arise from a direct or indirect association with microtubules.
PSTPIP1 Binding (association) of
12) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
Similarly, in previous studies using immunoprecipitation, mutations in pyrin did not modify its interaction with PSTPIP1 [5].
PSTPIP1 Neg (not) Binding (interaction) of
13) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.15 Pain Relevance 0
Finally, we examine the binding relationships between PSTPIP1, pyrin, and the pyrin-binding protein ASC.
PSTPIP1 Spec (examine) Binding (binding) of
14) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.18 Pain Relevance 0.04
To explore the effect of PAPA mutations on the PSTPIP1:pyrin interaction, we next tested whether the filaments formed by mutant forms of PSTPIP1 could be reorganized by pyrin.
PSTPIP1 Binding (interaction) of in filaments
15) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.15 Pain Relevance 0
Finally, we directly test the binding relationships between PSTPIP1, pyrin, and the pyrin-binding protein ASC.
PSTPIP1 Binding (binding) of
16) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.37 Pain Relevance 0.04
In the remaining cells, PSTPIP1 is not associated with specks (Figure 9K–P).
PSTPIP1 Binding (associated) of
17) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
Additionally, a mutation in the CC region of PSTPIP1, W232A, abolished PSTPIP1 binding both to pyrin [5] and to the PEST phosphatase, PTP-HSCF [8].
PSTPIP1 Binding (binding) of
18) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
Indeed, the F-BAR domains of both PSTPIP1 and PSTPIP2 can bind to artificial liposomes containing phosphatidyl inositol (4,5) bisphosphate (PI(4,5)P2) with high affinity [19].
PSTPIP1 Binding (bind) of
19) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
The binding of PSTPIP1 and pyrin was previously studied by immunoprecipitation and the SH3 domain of PSTPIP1 was found to be necessary but not sufficient for this interaction [5].
PSTPIP1 Binding (binding) of in SH3
20) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox