INT194106

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.34
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (MKLN1) cytoplasm (MKLN1)
MKLN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 12 99.98 Very High Very High Very High
potassium channel 4 99.10 Very High Very High Very High
action potential duration 24 98.36 Very High Very High Very High
sodium channel 4 88.80 High High
Action potential 4 86.76 High High
Angina 4 62.48 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 8 99.98 Very High Very High Very High
Arrhythmias 2 Under Development 24 99.32 Very High Very High Very High
Hypertrophic Cardiomyopathy 20 98.72 Very High Very High Very High
Heart Arrhythmia 16 98.12 Very High Very High Very High
Heart Rate Under Development 108 96.40 Very High Very High Very High
Syndrome 20 94.68 High High
Arrhythmia Under Development 16 93.72 High High
Myocardial Infarction 100 92.96 High High
Congenital Anomalies 8 87.60 High High
Cardiomyopathy 16 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of TWA for prognosis in patients with HCM needs to be elucidated.


Positive_regulation (role) of TWA associated with hypertrophic cardiomyopathy
1) Confidence 0.25 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1513519 Disease Relevance 1.31 Pain Relevance 0.04
Potassium channels may also play an important role in ischemia-induced TWA.
Positive_regulation (induced) of TWA associated with ischemia and potassium channel
2) Confidence 0.25 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1513519 Disease Relevance 1.03 Pain Relevance 0.33
In patients with the Brugada syndrome, some reports have revealed that intravenous administration of class Ic antiarrhythmic drugs induced macroscopic TWA and resulted in VF [23,24].
Positive_regulation (induced) of TWA associated with heart arrhythmia and arrhythmias 2 under development
3) Confidence 0.23 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1513519 Disease Relevance 1.62 Pain Relevance 0.09
The critical pacing rate induced concordant TWA, which developed to discordant alternans of APD and increased susceptibility to ventricular tachyarrhythmias.


Positive_regulation (induced) of TWA associated with heart rate under development and action potential duration
4) Confidence 0.23 Published 2003 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1513519 Disease Relevance 0.38 Pain Relevance 0.18

General Comments

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