INT194127

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
pituitary 2
cervix 2
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 1 100.00 Very High Very High Very High
Hippocampus 2 97.76 Very High Very High Very High
corticosteroid 5 92.52 High High
cytokine 6 90.40 High High
Dopamine 2 83.28 Quite High
antagonist 2 74.72 Quite High
depression 2 73.04 Quite High
nMDA receptor 1 42.72 Quite Low
Opioid 1 28.28 Quite Low
gABA 1 26.60 Quite Low
Disease Link Frequency Relevance Heat
Pre-term Labor 10 90.60 High High
Depression 2 73.04 Quite High
Cancer 92 5.00 Very Low Very Low Very Low
Apoptosis 34 5.00 Very Low Very Low Very Low
Death 21 5.00 Very Low Very Low Very Low
Stress 17 5.00 Very Low Very Low Very Low
Premature Birth 11 5.00 Very Low Very Low Very Low
Necrosis 7 5.00 Very Low Very Low Very Low
Melanoma 6 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This analysis revealed down-regulation of the levels of both CRH-R2 and CRH-BP mRNA in the cervix in connection with labor.
Negative_regulation (regulation) of Transcription (levels) of CRH in cervix
1) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.09 Pain Relevance 0.20
It also affected the transcription of genes involved in the regulation of the hypothalamic┬ľpituitary┬ľadrenal axis: mRNA levels of both corticotropin-releasing factor (CRF) and serotonin 5-HT1A receptor were decreased in the hypothalamic paraventricular nucleus and in the hippocampus, respectively [136].
Negative_regulation (decreased) of Transcription (levels) of corticotropin-releasing factor in pituitary associated with hippocampus and serotonin
2) Confidence 0.06 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 0.07 Pain Relevance 0.31

General Comments

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