INT19421

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Context Info
Confidence 0.49
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 5.63
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RIPK2) signal transduction (RIPK2) intracellular (RIPK2)
cytoplasm (RIPK2) signal transducer activity (RIPK2)
Anatomy Link Frequency
plasma 2
bowel 1
RIPK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 19 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
Inflammation 19 99.36 Very High Very High Very High
spastic colon 6 99.16 Very High Very High Very High
Somatostatin 2 99.12 Very High Very High Very High
Chronic pancreatitis 13 98.96 Very High Very High Very High
Bile 1 93.76 High High
Pain 3 75.04 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 99.36 Very High Very High Very High
Functional Bowel Disorder 2 99.16 Very High Very High Very High
Pancreatitis 18 98.96 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 98.12 Very High Very High Very High
Apoptosis 82 93.96 High High
Diarrhoea 1 86.88 High High
Constipation 1 85.92 High High
Acute Renal Failure 166 85.64 High High
Burns 148 85.20 High High
Injury 30 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have described previously that the gallbladder responds abnormally to infusions of cholecystokinin octapeptide (CCK-8) in patients with irritable bowel syndrome (IBS).
Positive_regulation (infusions) of CCK in bowel associated with spastic colon and cholecystokinin
1) Confidence 0.49 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 2058671 Disease Relevance 0.35 Pain Relevance 0.50
Useful parameters included 10-min secretory volume and 10-min bicarbonate output after secretin stimulation, and 10-min enzyme output after CCK-PZ stimulation (lipase output showed higher sensitivity than amylase output).
Positive_regulation (stimulation) of CCK
2) Confidence 0.49 Published 1988 Journal Gastroenterol. Jpn. Section Abstract Doc Link 3402703 Disease Relevance 0.30 Pain Relevance 0.35
Postprandial responses of plasma cholecystokinin (CCK) in patients with severe chronic pancreatitis (n = 7) were studied.
Positive_regulation (responses) of CCK in plasma associated with chronic pancreatitis and cholecystokinin
3) Confidence 0.49 Published 1985 Journal Am. J. Gastroenterol. Section Abstract Doc Link 4073000 Disease Relevance 0.25 Pain Relevance 0.54
However, such significant plasma CCK response to the meal was not observed in patients with chronic pancreatitis in whom CCK levels rose from a basal level of 9.7 +/- 0.91 pg/ml to a peak of 13.8 +/- 1.6 pg/ml at 60 min.
Positive_regulation (response) of CCK in plasma associated with chronic pancreatitis and cholecystokinin
4) Confidence 0.49 Published 1985 Journal Am. J. Gastroenterol. Section Abstract Doc Link 4073000 Disease Relevance 0.26 Pain Relevance 0.65
In the treatment of acute pancreatitis, prophylactic antibiotics, somatostatin, protease inhibitors, and cholecystokinin (CCK)-receptor antagonists are advocated for use in the early stages of acute pancreatitis, but the data are insufficient to mandate prophylaxis use or recommend their use as a standard of care.
Positive_regulation (advocated) of CCK associated with antagonist, pancreatitis, somatostatin and cholecystokinin
5) Confidence 0.49 Published 1998 Journal Pancreas Section Abstract Doc Link 9548690 Disease Relevance 0.72 Pain Relevance 0.51
In addition, the CD40 gene and its transduction factor TRAF-3, as well as the nuclear factor (NF)-kB activator Ripk2 gene, were up-regulated, suggesting an inflammatory activation of tubular cells (Figure 4F).
Positive_regulation (up) of Ripk2 associated with inflammation
6) Confidence 0.45 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.75 Pain Relevance 0.09
In addition, the CD40 gene and its transduction factor TRAF-3, as well as the nuclear factor (NF)-kB activator Ripk2 gene, were up-regulated, suggesting an inflammatory activation of tubular cells (Figure 4F).
Positive_regulation (regulated) of Ripk2 associated with inflammation
7) Confidence 0.45 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.76 Pain Relevance 0.09

General Comments

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