INT194242

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.10
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MBP)
Anatomy Link Frequency
T-cell 2
oligodendrocytes 2
MBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 47 99.52 Very High Very High Very High
withdrawal 2 99.04 Very High Very High Very High
Central nervous system 71 97.72 Very High Very High Very High
unmyelinated 7 94.08 High High
Multiple sclerosis 28 91.84 High High
Pain 90 88.64 High High
Nav1.7 85 88.28 High High
Demyelination 55 87.28 High High
tolerance 9 82.84 Quite High
imagery 12 80.24 Quite High
Disease Link Frequency Relevance Heat
Disease 36 99.84 Very High Very High Very High
INFLAMMATION 44 99.52 Very High Very High Very High
Multiple Sclerosis 281 97.56 Very High Very High Very High
Stroke 9 97.24 Very High Very High Very High
Encephalitis 6 97.12 Very High Very High Very High
Sepsis 10 94.20 High High
Brain Injury 28 94.08 High High
Demyelinating Disease 97 91.84 High High
Death 6 91.84 High High
Head Trauma 1 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
T-cell-mediated inflammation was induced by passive transfer of myelin basic protein (MBP) reactive encephalitogenic T-cell lines.
Positive_regulation (transfer) of Gene_expression (transfer) of MBP in T-cell associated with inflammation
1) Confidence 0.45 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892605 Disease Relevance 1.45 Pain Relevance 0.52
The expression of MBP within normal samples was prominent on the surface of fibers located within axon bundles and less at nodal regions (Fig. 5A).
Positive_regulation (prominent) of Gene_expression (expression) of MBP
2) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.59
Serum levels of MBP are elevated in diseases in which there is myelin breakdown.
Positive_regulation (elevated) of Gene_expression (levels) of MBP associated with disease
3) Confidence 0.36 Published 2006 Journal Crit Care Section Body Doc Link PMC1794449 Disease Relevance 1.42 Pain Relevance 0.20
The production of MBP after the addition of T3 and withdrawal of growth factors corresponded with their maturation into OLs.
Positive_regulation (after) of Gene_expression (production) of MBP associated with withdrawal
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864763 Disease Relevance 0 Pain Relevance 0.05
(Fig. 1) as well as they can present MBP in animal models [41], [42], [43], the LMP2 60HH-dependent altered expression of the MBP epitopes (e.g.
Positive_regulation (dependent) of Gene_expression (expression) of MBP
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.48 Pain Relevance 0.17
In oligodendrocytes, a decreased presentation mediated by the LMP2 60HH variant of MBP epitopes (e.g.
Positive_regulation (mediated) of Gene_expression (variant) of MBP in oligodendrocytes
6) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.56 Pain Relevance 0.15
We propose that such an effect is mediated by the altered proteasome-dependent production of a specific MBP epitope presented on the MHC class I.
Positive_regulation (dependent) of Gene_expression (production) of MBP
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2823778 Disease Relevance 0.19 Pain Relevance 0
In addition, expression of GFAP and MBP increased after induction in transfected cells.
Positive_regulation (increased) of Gene_expression (expression) of MBP
8) Confidence 0.12 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0 Pain Relevance 0.04
A control for induction and maltose binding protein (MBP) expression was also run using pMal-c2x transformants.
Positive_regulation (induction) of Gene_expression (expression) of MBP
9) Confidence 0.09 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523344 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox