INT19427

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Context Info
Confidence 0.04
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.55
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTRF1) cytoplasm (MTRF1)
Anatomy Link Frequency
saliva 2
MTRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 80 99.68 Very High Very High Very High
rheumatoid arthritis 83 95.44 Very High Very High Very High
methotrexate 32 94.04 High High
spinal inflammation 1 64.04 Quite High
Analgesic 2 56.08 Quite High
cINOD 2 55.36 Quite High
corticosteroid 2 52.64 Quite High
Infliximab 22 5.00 Very Low Very Low Very Low
Etanercept 12 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Salivary Gland Disease 2 99.36 Very High Very High Very High
Rheumatoid Arthritis 83 95.44 Very High Very High Very High
Disease 22 95.36 Very High Very High Very High
Communicable Diseases 2 89.92 High High
Autoimmune Disease 4 78.36 Quite High
Infection 6 77.40 Quite High
Vasculitis 1 65.80 Quite High
Asthma 1 64.76 Quite High
Low Back Pain 1 64.04 Quite High
Systemic Lupus Erythematosus 11 63.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modification of anti-CCP antibody and RF titers during adalimumab treatment
Regulation (Modification) of Gene_expression (titers) of RF associated with adalimumab
1) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.24 Pain Relevance 0.17
Detection of RF and anti-CCP autoantibodies
Regulation (autoantibodies) of Gene_expression (Detection) of RF
2) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.45 Pain Relevance 0.28
The results of this study show that 1) IgA-RF in serum and SF is mainly of IgA1 subclass, 2) both IgA-RF subclasses are produced locally in salivary glands and in synovial tissue, 3) the production of both IgA-RF subclasses at mucosal and nonmucosal sites is independent from each other, and 4) both IgA-RF subclasses occur predominantly in polymeric form in serum, SF, and saliva in RA patients.
Regulation (independent) of Gene_expression (production) of RF in saliva associated with salivary gland disease and rheumatoid arthritis
3) Confidence 0.03 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 2059231 Disease Relevance 0.86 Pain Relevance 0.25
The lack of any effect on MuRF-1 protein expression and the paradoxical rise at the highest insulin availability are also puzzling, since they do not match the observed behavior of LPB.
Regulation (effect) of Gene_expression (expression) of MuRF-1
4) Confidence 0.01 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0

General Comments

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