INT19428

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Context Info
Confidence 0.08
First Reported 1991
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 42
Total Number 43
Disease Relevance 27.17
Pain Relevance 10.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTRF1) cytoplasm (MTRF1)
Anatomy Link Frequency
B cells 8
synovium 3
T cell 3
saliva 2
macrophage 1
MTRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1440 100.00 Very High Very High Very High
Adalimumab 240 99.68 Very High Very High Very High
Infliximab 221 99.52 Very High Very High Very High
Inflammation 203 99.44 Very High Very High Very High
tolerance 89 99.32 Very High Very High Very High
cytokine 79 98.72 Very High Very High Very High
Arthritis 28 97.48 Very High Very High Very High
agonist 4 96.54 Very High Very High Very High
methotrexate 276 96.28 Very High Very High Very High
fibrosis 15 93.44 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1442 100.00 Very High Very High Very High
Hyperinsulinism 12 99.86 Very High Very High Very High
Disease 541 99.52 Very High Very High Very High
Salivary Gland Disease 9 99.52 Very High Very High Very High
INFLAMMATION 208 99.44 Very High Very High Very High
Hepatitis C Virus Infection 84 99.44 Very High Very High Very High
Apoptosis 105 99.12 Very High Very High Very High
Autoimmune Disease 49 99.04 Very High Very High Very High
Syndrome 83 98.66 Very High Very High Very High
Infection 88 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of this study show that 1) IgA-RF in serum and SF is mainly of IgA1 subclass, 2) both IgA-RF subclasses are produced locally in salivary glands and in synovial tissue, 3) the production of both IgA-RF subclasses at mucosal and nonmucosal sites is independent from each other, and 4) both IgA-RF subclasses occur predominantly in polymeric form in serum, SF, and saliva in RA patients.
Gene_expression (production) of RF in saliva associated with salivary gland disease and rheumatoid arthritis
1) Confidence 0.08 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 2059231 Disease Relevance 0.86 Pain Relevance 0.25
Comparison of RF levels in samples of serum, synovial fluid (SF), and saliva from RA patients indicated local production of both IgA-RF subclasses in salivary glands and in synovial tissue.
Gene_expression (production) of RF in salivary glands associated with salivary gland disease and rheumatoid arthritis
2) Confidence 0.08 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 2059231 Disease Relevance 0.94 Pain Relevance 0.26
The results of this study show that 1) IgA-RF in serum and SF is mainly of IgA1 subclass, 2) both IgA-RF subclasses are produced locally in salivary glands and in synovial tissue, 3) the production of both IgA-RF subclasses at mucosal and nonmucosal sites is independent from each other, and 4) both IgA-RF subclasses occur predominantly in polymeric form in serum, SF, and saliva in RA patients.
Gene_expression (produced) of RF in saliva associated with salivary gland disease and rheumatoid arthritis
3) Confidence 0.08 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 2059231 Disease Relevance 0.89 Pain Relevance 0.25
Elevated serum levels of IgA, IgA1, and IgA2 rheumatoid factors (RF) were demonstrated by enzyme-linked immunosorbent assay in 69%, 73%, and 36%, respectively, of 100 patients with rheumatoid arthritis (RA), whereas fewer than 5% of 100 healthy donor sera contained elevated levels of these RFs.
Gene_expression (levels) of RF associated with rheumatoid arthritis
4) Confidence 0.07 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 2059231 Disease Relevance 0.61 Pain Relevance 0.20
RF can be detected in up to 70–80% of RA patients [11].
Gene_expression (detected) of RF associated with rheumatoid arthritis
5) Confidence 0.06 Published 2008 Journal Rheumatol Int Section Body Doc Link PMC2493537 Disease Relevance 1.43 Pain Relevance 0.51
Modification of anti-CCP antibody and RF titers during adalimumab treatment
Gene_expression (titers) of RF associated with adalimumab
6) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.24 Pain Relevance 0.17
The value of anti-CCP antibodies and RF for predicting the outcome of RA, clinical signs of disease activity, and the severity of radiographic joint damage has been investigated recently.
Gene_expression (antibodies) of RF in joint associated with rheumatoid arthritis and disease
7) Confidence 0.06 Published 2008 Journal Rheumatol Int Section Body Doc Link PMC2493537 Disease Relevance 1.10 Pain Relevance 0.47
Although T cell and macrophage populations dominate the current theories of pathogenesis of RA, there is emerging evidence that B cells and their production of RF may also be intrinsic to RA (Mitchison et al 2000).
Gene_expression (production) of RF in T cell associated with rheumatoid arthritis
8) Confidence 0.05 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 1.17 Pain Relevance 0.43
Such an effect is associated with a decrease in serum levels of RF and anti-CCP antibody levels, which was detected after 24 weeks and remained stable until 48 weeks of treatment.
Gene_expression (detected) of RF
9) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.40 Pain Relevance 0.16
Such an effect is associated with a decrease in serum levels of RF and anti-CCP antibody levels, which was detected after 24 weeks and remained stable until 48 weeks of treatment.
Gene_expression (levels) of RF
10) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.35 Pain Relevance 0.16
Tests for IgM RF and anti-CCP autoantibodies were performed at baseline and after 6 and 12 months of adalimumab treatment.
Gene_expression (autoantibodies) of RF associated with adalimumab
11) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.43 Pain Relevance 0.25
Detection of RF and anti-CCP autoantibodies
Gene_expression (Detection) of RF
12) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.45 Pain Relevance 0.28
Although no patients who were positive for anti-CCP or RF at baseline became negative after anti-TNF-?
Gene_expression (positive) of RF
13) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.17 Pain Relevance 0.17
This suggests that RF in RA patients is produced in response to an antigen/T cell-driven process of somatic mutation of the immunoglobulin gene sequence.
Gene_expression (produced) of RF in T cell associated with rheumatoid arthritis
14) Confidence 0.05 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 1.35 Pain Relevance 0.48
There is also differentiation of B cells into plasma cells, thus maintaining them in germinal centres in a state of continuous RF production.
Gene_expression (production) of RF in B cells
15) Confidence 0.05 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.49 Pain Relevance 0.15
In contrast, the RF produced by normal individuals in response to infection or immunization is usually IgM, transient, with low affinity, and of germ line origin suggesting it is part of the innate immune response (Thompson et al 1995).
Gene_expression (produced) of RF in germ line associated with immunization and infection
16) Confidence 0.05 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 1.31 Pain Relevance 0.49
There are two major theories that have been postulated to explain the role of RF in the RA inflammatory process and the reason for RF overproduction: i) The loss of tolerance model due to CD40–CD40L activation signals (Kyburz et al 1999); ii) The autonomous mutated B cell model (Edwards et al 1999).
Gene_expression (overproduction) of RF in B cell associated with inflammation, tolerance and rheumatoid arthritis
17) Confidence 0.05 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 1.01 Pain Relevance 0.49
However, since RF is detected in only 50-80% of RA sera (2) and frequently present in patients with other autoimmune disease and in the elderly healthy population (3), diagnosis of RA using RF assay remains suboptimal.
Gene_expression (detected) of RF associated with autoimmune disease and rheumatoid arthritis
18) Confidence 0.04 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782206 Disease Relevance 1.04 Pain Relevance 0.43
The RA syndrome and, in particular, extraarticular disease is associated with the production of the autoantibody known as rheumatoid factor (RF).
Gene_expression (production) of RF associated with syndrome, rheumatoid arthritis and disease
19) Confidence 0.04 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 1.85 Pain Relevance 0.55
B cells are the source of both RF and IL-6 thus potentiating their own secretion of autoantibody.
Gene_expression (source) of RF in B cells
20) Confidence 0.04 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.82 Pain Relevance 0.38

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