INT194289

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Context Info
Confidence 0.72
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 3.56
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT)
plasma membrane (COMT) cytoplasm (COMT)
Anatomy Link Frequency
stem 1
COMT (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 792 100.00 Very High Very High Very High
Fibrositis 17 99.88 Very High Very High Very High
Pain 156 93.28 High High
Catecholamine 46 83.76 Quite High
backache 1 54.20 Quite High
IPN 6 47.96 Quite Low
allodynia 2 17.92 Low Low
Hyperalgesia 1 16.20 Low Low
Dopamine 19 14.56 Low Low
Glutamate 7 14.32 Low Low
Disease Link Frequency Relevance Heat
Fibromyalgia 5 99.88 Very High Very High Very High
Schizophrenia 31 99.64 Very High Very High Very High
Pain 156 93.28 High High
Hantavirus Infection 468 89.04 High High
Cognitive Disorder 42 81.80 Quite High
Low Back Pain 1 54.20 Quite High
Hyperhomocysteinemia 12 51.76 Quite High
Inflammatory Pain 6 47.96 Quite Low
Neurodegenerative Disease 12 42.00 Quite Low
Cardiovascular Disease 12 39.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
untranslated region was associated with Schizophrenia [35] and reduced expression of COMT mRNA [57].
Transcription (expression) of COMT associated with catechol-o-methyltransferase and schizophrenia
1) Confidence 0.72 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.65 Pain Relevance 0.30
Genotyping of the COMT locus
Transcription (Genotyping) of COMT associated with catechol-o-methyltransferase
2) Confidence 0.69 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1524765 Disease Relevance 0.77 Pain Relevance 0.76
Construction of COMT variants
Transcription (Construction) of COMT associated with catechol-o-methyltransferase
3) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.46 Pain Relevance 0.20
regulates COMT expression, we cloned the human distal COMT promoter (P2-COMT) which controls transcription of MB-COMT mRNA (Figure 2A).
Transcription (transcription) of MB-COMT mRNA associated with catechol-o-methyltransferase
4) Confidence 0.62 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0 Pain Relevance 0.55
Using an approach similar to that used previously [69], we first performed a BLAST search of the human EST database (dbEST release May 09, 2008) to identify all allelic combinations occurring within the complete nucleotide sequence of MB-COMT mRNA (NM_000754.2, length?
Transcription (length) of MB-COMT associated with catechol-o-methyltransferase
5) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.35 Pain Relevance 0.41
Suboptimal stem-loop structures were analyzed by the Hybrid program [72], [73] for the full-length COMT transcripts, and for truncated transcript sequences of different lengths ranging from the rs4633 to the rs769224 region with 449 nucleotide window length.


Spec (analyzed) Transcription (transcripts) of COMT in stem associated with catechol-o-methyltransferase
6) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.46 Pain Relevance 0.22
SEAP was used to normalize COMT RNA abundance for transfection efficiency.
Transcription (abundance) of COMT associated with catechol-o-methyltransferase
7) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0 Pain Relevance 0.21
Effect of minor SNPs on COMT RNA abundance, protein expression, and enzymatic activity
Transcription (abundance) of COMT associated with catechol-o-methyltransferase
8) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.88 Pain Relevance 0.08

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