INT19429

Context Info Confidence 0.08 First Reported 1991 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.62 Pain Relevance 0.75

mitochondrion (MTRF1) cytoplasm (MTRF1)

MTRF1 (Homo sapiens)

Pain Link Frequency Relevance Heat spinal inflammation 2 98.42 Adalimumab 40 96.60 rheumatoid arthritis 69 90.72 Infliximab 42 75.00 methotrexate 23 66.24 Analgesic 1 54.32 cINOD 2 53.60 corticosteroid 1 50.88 Etanercept 8 5.00 Inflammation 3 5.00

Disease Link Frequency Relevance Heat Vasculitis 1 99.30 Asthma 1 98.78 Low Back Pain 2 98.42 Systemic Lupus Erythematosus 19 97.94 Chronic Disease 1 97.34 Rheumatoid Arthritis 69 90.72 Communicable Diseases 2 88.16 Salivary Gland Disease 2 85.28 Autoimmune Disease 3 76.60 Infection 4 75.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In serum samples from 125 controls with 4 different chronic diseases (systemic lupus erythematosus, ankylosing spondylitis, bronchial asthma, and polyarteritis nodosa), levels of IgA-, IgA1-, and IgA2-RF were found to be increased in 7%, 7%, and 8%, respectively.

Positive_regulation (increased) of RF associated with asthma, spinal inflammation, vasculitis, systemic lupus erythematosus and chronic disease

1) Confidence 0.08 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 2059231 Disease Relevance 0.91 Pain Relevance 0.26

Tests for IgM RF and anti-CCP autoantibodies were performed at baseline and after 6 and 12 months of adalimumab treatment.

Positive_regulation (Tests) of RF associated with adalimumab

2) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.44 Pain Relevance 0.25

The proportion of patients who were positive for rheumatoid factor (RF) was similar at baseline and at 78 weeks (87% and 80%, respectively).

Positive_regulation (positive) of RF

3) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC416448 Disease Relevance 0.28 Pain Relevance 0.24

General Comments

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