INT194298

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 8.84
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DHPS) translation (DHPS)
Anatomy Link Frequency
internal 1
DHPS (Homo sapiens)
Pain Link Frequency Relevance Heat
peripheral neuropathy 15 94.40 High High
withdrawal 10 86.64 High High
Inflammation 65 80.52 Quite High
methotrexate 5 70.32 Quite High
cINOD 5 15.64 Low Low
Calcium channel 5 13.40 Low Low
anticonvulsant 5 11.64 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 345 100.00 Very High Very High Very High
Disease 70 99.92 Very High Very High Very High
Fever 35 99.32 Very High Very High Very High
Hypersensitivity 60 96.44 Very High Very High Very High
Adverse Drug Reaction 5 96.36 Very High Very High Very High
Peripheral Neuropathy 15 94.40 High High
Hematologic Neoplasms 5 94.40 High High
Cytomegalovirus Infection 15 93.96 High High
Hemolytic Anemia 15 93.48 High High
Vasculitis 25 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Molecular and immunopathogenesis of DHS
Gene_expression (Molecular) of DHS associated with syndrome
1) Confidence 0.62 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1524788 Disease Relevance 1.61 Pain Relevance 0
A high index of suspicion is needed for early diagnosis of DHS.
Gene_expression (diagnosis) of DHS associated with syndrome
2) Confidence 0.54 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1524788 Disease Relevance 1.61 Pain Relevance 0.11
DHS typically presents with a triad of fever, skin eruption, and internal organ (lung, liver, neurological and other systems) involvement, occurring several weeks to as late as 6 months after the initial administration of the drug.
Gene_expression (presents) of DHS in internal associated with syndrome and fever
3) Confidence 0.54 Published 2006 Journal J Occup Med Toxicol Section Abstract Doc Link PMC1524788 Disease Relevance 2.19 Pain Relevance 0.09
Patients initiated on dapsone for various indications need to be observed carefully for the development of the DHS.
Gene_expression (development) of DHS associated with syndrome
4) Confidence 0.54 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1524788 Disease Relevance 1.55 Pain Relevance 0.11
Based on the clinical picture of multisystem involvement, lack of a defining microbiological cause and the progression of disease, a diagnosis of DHS was made.
Gene_expression (diagnosis) of DHS associated with syndrome and disease
5) Confidence 0.54 Published 2006 Journal J Occup Med Toxicol Section Body Doc Link PMC1524788 Disease Relevance 1.87 Pain Relevance 0.06

General Comments

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