INT19430

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 6.42
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
articular 2
bowel 2
T cells 1
IGHA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 18 98.74 Very High Very High Very High
nud 4 97.98 Very High Very High Very High
spastic colon 2 97.34 Very High Very High Very High
abatacept 5 94.48 High High
rheumatoid arthritis 7 90.72 High High
Antihistamine 4 89.12 High High
anakinra 18 88.92 High High
cytokine 2 81.04 Quite High
Pain 5 78.24 Quite High
intrathecal 4 66.56 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 10 100.00 Very High Very High Very High
Vasculitis 1 99.62 Very High Very High Very High
Asthma 1 99.10 Very High Very High Very High
Syndrome 16 98.92 Very High Very High Very High
Low Back Pain 18 98.74 Very High Very High Very High
Iritis 2 98.32 Very High Very High Very High
Systemic Lupus Erythematosus 3 98.26 Very High Very High Very High
Dyspepsia 2 97.98 Very High Very High Very High
Chronic Disease 1 97.66 Very High Very High Very High
Functional Bowel Disorder 2 97.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A polyclonal increase in IgG and IgA was noted with an associated small (< 1 g/L) IgM kappa paraprotein.
Positive_regulation (increase) of IgA
1) Confidence 0.67 Published 2008 Journal Cases J Section Body Doc Link PMC2612653 Disease Relevance 1.51 Pain Relevance 0.26
Although we found modest elevation of anti-glutamic acid decarboxylase (GAD) and IgA anti-gliadin antibodies in the serum of one case (Patient 1), the role of these antibodies in the pathogenesis of this disorder is uncertain because of their absence intrathecally.
Positive_regulation (elevation) of IgA associated with generalized anxiety disorder
2) Confidence 0.67 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1351204 Disease Relevance 1.14 Pain Relevance 0
In serum samples from 125 controls with 4 different chronic diseases (systemic lupus erythematosus, ankylosing spondylitis, bronchial asthma, and polyarteritis nodosa), levels of IgA-, IgA1-, and IgA2-RF were found to be increased in 7%, 7%, and 8%, respectively.
Positive_regulation (increased) of IgA1 associated with asthma, spinal inflammation, vasculitis, systemic lupus erythematosus and chronic disease
3) Confidence 0.62 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 2059231 Disease Relevance 0.91 Pain Relevance 0.27
Similarly increased serum IgA1 and IgA2 subclass antibody levels against Klebsiella pneumoniae bacteria in ankylosing spondylitis patients with/without extra-articular features.
Positive_regulation (increased) of IgA1 in articular associated with spinal inflammation
4) Confidence 0.54 Published 1996 Journal Br. J. Rheumatol. Section Title Doc Link 8612022 Disease Relevance 0.50 Pain Relevance 0.48
The previous findings of increased IgA1 and IgA2 subclass antibody levels against K. pneumoniae in AS patients when compared to the healthy controls were not specifically associated with any single AS patient group in the present study, but instead were similarly seen in all patient groups with/without extra-articular features.
Positive_regulation (increased) of IgA1 in articular associated with spinal inflammation
5) Confidence 0.54 Published 1996 Journal Br. J. Rheumatol. Section Abstract Doc Link 8612022 Disease Relevance 0.55 Pain Relevance 0.52
Significant elevations of IgA1 antibodies against type II collagen (p < 0.01) and IgA2 antibodies against type I (p < 0.001), III (p < 0.001), and IV (p < 0.01) collagens were observed in AS patients compared with those of healthy controls.
Positive_regulation (elevations) of IgA1 associated with spinal inflammation
6) Confidence 0.48 Published 1997 Journal Scand. J. Rheumatol. Section Abstract Doc Link 9385351 Disease Relevance 0.36 Pain Relevance 0.44
Anti-gliadin antibody (IgA-type) was elevated in serum (42.1 EU, normal 0–29.9, ARUP Laboratories, Salt Lake City, Utah), but anti-gliadin antibody (IgG-type) and anti-transglutaminase antibodies were normal or undetectable.
Positive_regulation (elevated) of IgA
7) Confidence 0.45 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1351204 Disease Relevance 0.83 Pain Relevance 0.03
Twenty adult subjects with small intestinal bacterial overgrowth (N = 13), irritable bowel syndrome (N = 4), and nonulcer dyspepsia (N = 3) underwent endoscopic aspiration of secretions from the small intestinal mucosal surface for assessment of IL-6, IgA1, IgA2, IgM, IgG1, IgG2, IgG3, and IgG4 concentrations.
Positive_regulation (assessment) of IgA1 in bowel associated with spastic colon and nud
8) Confidence 0.45 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9512143 Disease Relevance 0.27 Pain Relevance 0.15
Twenty adult subjects with small intestinal bacterial overgrowth (N = 13), irritable bowel syndrome (N = 4), and nonulcer dyspepsia (N = 3) underwent endoscopic aspiration of secretions from the small intestinal mucosal surface for assessment of IL-6, IgA1, IgA2, IgM, IgG1, IgG2, IgG3, and IgG4 concentrations.
Positive_regulation (assessment) of IgG1 in bowel associated with spastic colon and nud
9) Confidence 0.20 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9512143 Disease Relevance 0.27 Pain Relevance 0.15
of human IgG1 to increase its serum half- life.21 Given the higher affinity of CTLA4 for CD80/86, CTLA4-Ig should theoretically block antigen-presenting cell stimulation of T cells through CD28, thereby terminating the immune response (see Figure 1).
Positive_regulation (increase) of IgG1 in T cells
10) Confidence 0.01 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998809 Disease Relevance 0.08 Pain Relevance 0.29

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