INT19431

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Context Info
Confidence 0.05
First Reported 1991
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.13
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTRF1) cytoplasm (MTRF1)
Anatomy Link Frequency
B-cell 2
synovium 2
saliva 2
MTRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 98.84 Very High Very High Very High
Adalimumab 80 97.72 Very High Very High Very High
rheumatoid arthritis 114 95.44 Very High Very High Very High
Infliximab 53 86.08 High High
methotrexate 39 80.92 Quite High
spinal inflammation 2 64.04 Quite High
Analgesic 2 54.32 Quite High
cINOD 3 53.60 Quite High
corticosteroid 4 50.88 Quite High
Etanercept 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 84 99.60 Very High Very High Very High
Salivary Gland Disease 3 99.36 Very High Very High Very High
INFLAMMATION 8 98.84 Very High Very High Very High
Lymphatic System Cancer 17 96.64 Very High Very High Very High
Rheumatoid Arthritis 114 95.44 Very High Very High Very High
Communicable Diseases 3 88.16 High High
Disease 58 82.24 Quite High
Autoimmune Disease 10 76.60 Quite High
Infection 32 75.64 Quite High
Ulcers 4 68.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of this study show that 1) IgA-RF in serum and SF is mainly of IgA1 subclass, 2) both IgA-RF subclasses are produced locally in salivary glands and in synovial tissue, 3) the production of both IgA-RF subclasses at mucosal and nonmucosal sites is independent from each other, and 4) both IgA-RF subclasses occur predominantly in polymeric form in serum, SF, and saliva in RA patients.
Positive_regulation (independent) of Gene_expression (production) of RF in saliva associated with salivary gland disease and rheumatoid arthritis
1) Confidence 0.05 Published 1991 Journal Arthritis Rheum. Section Abstract Doc Link 2059231 Disease Relevance 0.86 Pain Relevance 0.25
Tests for IgM RF and anti-CCP autoantibodies were performed at baseline and after 6 and 12 months of adalimumab treatment.
Positive_regulation (Tests) of Gene_expression (autoantibodies) of RF associated with adalimumab
2) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.44 Pain Relevance 0.25
Although no patients who were positive for anti-CCP or RF at baseline became negative after anti-TNF-?
Positive_regulation (for) of Gene_expression (positive) of RF
3) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.17 Pain Relevance 0.17
Because RF-producing cells are present in inflamed rheumatoid synovium and the local environment may favour synovial RF production [40], we can speculate that the reduction in inflammatory lymphoplasmacytic infiltrate in rheumatoid synovium will lead to a reduced production of RF.
Positive_regulation (lead) of Gene_expression (production) of RF in synovium associated with inflammation
4) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 0.39 Pain Relevance 0.29
In turn, HCV-VLDL complexes may trigger RF production as consequence of somatic mutations of WA clones; the possible evolution to B-cell lymphomas might be the consequence of the accumulation of stochastic genetic aberrations [59].
Spec (may) Positive_regulation (trigger) of Gene_expression (production) of RF in B-cell associated with lymphatic system cancer and hepatitis c virus infection
5) Confidence 0.01 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2569912 Disease Relevance 1.27 Pain Relevance 0

General Comments

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