INT194332

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MFN2) mitochondrion (MFN2) GTPase activity (MFN2)
MFN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
peripheral neuropathy 12 95.16 Very High Very High Very High
Multiple sclerosis 10 77.72 Quite High
Migraine 4 7.52 Low Low
headache 3 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Action potential 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Optic Atrophy 16 98.24 Very High Very High Very High
Peripheral Neuropathy 14 95.16 Very High Very High Very High
Neuropathic Pain 8 89.00 High High
Disease 25 87.24 High High
Charcot Marie Tooth Disease 22 86.44 High High
Demyelinating Disease 13 77.72 Quite High
Parkinson's Disease 4 72.96 Quite High
Leber Hereditary Optic Atrophy 3 64.20 Quite High
Neuropathy 7 52.44 Quite High
Spasticity 7 51.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MFN2 is localized to the outer mitochondrial membrane.
Localization (localized) of MFN2
1) Confidence 0.74 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1524942 Disease Relevance 0.26 Pain Relevance 0.03
Mitofusin-2 is located within the mitochondrial outer membrane and it shares a high degree of structural and functional complementarity with Opa1, both being dynamin GTPase proteins (Zuchner et al., 2006; Chan, 2007).
Localization (located) of Mitofusin-2
2) Confidence 0.62 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 1.18 Pain Relevance 0.12

General Comments

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