INT194335

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.64
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefl) locomotion (Nefl)
Anatomy Link Frequency
neurons 5
amacrine cells 3
retina 2
neuronal 1
Nefl (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 39 97.76 Very High Very High Very High
Glutamate 22 94.88 High High
gABA 30 93.44 High High
cytokine 18 90.52 High High
dorsal root ganglion 20 78.24 Quite High
Inflammation 52 47.08 Quite Low
Neuritis 3 30.64 Quite Low
anesthesia 10 24.32 Low Low
Spinal cord 44 24.04 Low Low
Sciatic nerve 31 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 431 99.86 Very High Very High Very High
Targeted Disruption 143 99.20 Very High Very High Very High
Injury 53 95.96 Very High Very High Very High
Infection 41 90.64 High High
Disease 46 87.60 High High
Sprains And Strains 12 85.20 High High
Toxocariasis 90 77.72 Quite High
Rheumatoid Arthritis 7 77.00 Quite High
Pressure And Volume Under Development 5 73.84 Quite High
Stress 2 62.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experiments using antibodies to NF-L, a neuronal cytoskeletal component that is expressed in most retinal ganglion cells, but not amacrine cells [28-30], showed that 61.6% of the CFP cells expressed NF-L immunoreactivity.
Neg (not) Gene_expression (expressed) of NF-L in amacrine cells associated with ganglion cysts
1) Confidence 0.51 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.93 Pain Relevance 0
Experiments using antibodies to NF-L, a neuronal cytoskeletal component that is expressed in most retinal ganglion cells, but not amacrine cells [28-30], showed that 61.6% of the CFP cells expressed NF-L immunoreactivity.
Gene_expression (expressed) of NF-L in amacrine cells associated with ganglion cysts
2) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.93 Pain Relevance 0
This pattern of NF-L expression was similar to that described in earlier studies [28-30].
Gene_expression (expression) of NF-L
3) Confidence 0.40 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.51 Pain Relevance 0
NF-L is an intermediate filament protein that is prominently expressed in mature neurons.
Gene_expression (expressed) of NF-L in neurons
4) Confidence 0.40 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.54 Pain Relevance 0
CFP expression was characterized using morphometric methods and immunohistochemistry with antibodies to neurofilament light (NF-L), neuronal nuclei (NeuN), POU-domain protein (Brn3a) and calretinin, which immunolabel ganglion cells, and syntaxin 1 (HPC-1), glutamate decarboxylase 67 (GAD67), GABA plasma membrane transporter-1 (GAT-1), and choline acetyltransferase (ChAT), which immunolabel amacrine cells.


Gene_expression (expression) of NF-L in amacrine cells associated with ganglion cysts, gaba and glutamate
5) Confidence 0.40 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2519030 Disease Relevance 0.41 Pain Relevance 0.09
This was less than expected, given that in the hamster retina 88% of all retinal ganglion cells express NF-L immunoreactivity [29].
Gene_expression (express) of NF-L in retina associated with ganglion cysts
6) Confidence 0.40 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.80 Pain Relevance 0
1, S100B, and NF-L mRNA expressions at 8 wpi (Figs. 5A, 6A)?
Gene_expression (expressions) of NF-L mRNA
7) Confidence 0.35 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 0.74 Pain Relevance 0.03
NF-L expression also greatly increased over time, with 1.4- and 7.5-fold increases at 4 and 8 wpi, respectively (Fig. 6A, B).
Gene_expression (expression) of NF-L
8) Confidence 0.31 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2442079 Disease Relevance 0.21 Pain Relevance 0.09
We identify M6a as a gene that is expressed in the embryonic retina and reveal the expression patterns of M6a in the neural processes, including the nerve fiber layer (NFL), inner plexiform layer (IPL), and outer plexiform layer (OPL), of the immature mouse retina.
Gene_expression (expression) of NFL in retina
9) Confidence 0.27 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0 Pain Relevance 0.09
Subdivision of ASIC3+ neurons into those with and those without NF68-immunoreactivity revealed that NF68+ neurons covered the whole size range up to 60 ?
Gene_expression (neurons) of NF68 in neurons
10) Confidence 0.23 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0 Pain Relevance 0
m, whereas NF68- neurons reached up to 40 ?
Gene_expression (whereas) of NF68 in neurons
11) Confidence 0.23 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0 Pain Relevance 0
Subdivision of ASIC3+ neurons into those with and those without NF68-immunoreactivity revealed that NF68+ neurons ranged from 20–45 ?
Gene_expression (neurons) of NF68 in neurons
12) Confidence 0.23 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0 Pain Relevance 0
m, whereas NF68- neurons ranged from below 20 to 40 ?
Gene_expression (whereas) of NF68 in neurons
13) Confidence 0.23 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0 Pain Relevance 0
During axon regeneration, the developmental pattern of IFs resumes: Vimentin is re-upregulated and expression of mature IFs such as NF-L and NF-H decreases [11]–[15], [17], [27], [32].
Gene_expression (expression) of NF-L
14) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.32 Pain Relevance 0.07
, neuronal markers for NF-L, astrocytic markers for GFAP, and oligodendroglial markers for MBP, were consistently expressed.
Gene_expression (expressed) of NF-L in neuronal
15) Confidence 0.12 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826742 Disease Relevance 0.26 Pain Relevance 0.13

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