INT194380

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 15.78
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL5) extracellular region (IL5)
Anatomy Link Frequency
eosinophil 8
blood 6
lung 5
thymocytes 4
helper T cells 4
IL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1000 100.00 Very High Very High Very High
cytokine 915 99.92 Very High Very High Very High
Inflammatory mediators 22 98.60 Very High Very High Very High
withdrawal 23 94.04 High High
corticosteroid 42 92.52 High High
Arthritis 62 89.28 High High
antiepileptic Drug 1 86.72 High High
methotrexate 37 86.40 High High
antagonist 314 85.64 High High
dexamethasone 11 85.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1067 100.00 Very High Very High Very High
Rhinitis 142 100.00 Very High Very High Very High
Hyperplasia 86 100.00 Very High Very High Very High
Apoptosis 87 99.84 Very High Very High Very High
Occupational Lung Diseases 160 99.40 Very High Very High Very High
Asthma 3138 99.28 Very High Very High Very High
Chronic Sinusitis 71 99.14 Very High Very High Very High
Cancer 39 98.84 Very High Very High Very High
Infection 158 96.28 Very High Very High Very High
Disease 294 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting that Liu and colleagues later showed a marked reduction in the expression of messenger ribonucleic acid of the surface IL-5 receptor (mIL-5R?)
Negative_regulation (reduction) of Gene_expression (expression) of IL-5
1) Confidence 0.42 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.41 Pain Relevance 0
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Negative_regulation (decreased) of Gene_expression (levels) of IL-5 in blood
2) Confidence 0.26 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.79 Pain Relevance 0.15
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Negative_regulation (decrease) of Gene_expression (levels) of IL-5 in blood
3) Confidence 0.26 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.81 Pain Relevance 0.15
Glucocorticoids decrease the levels of IL-5, which is one of the major growth factors for eosinophilic granulocytes (especially in eosinophilic conditions).
Negative_regulation (decrease) of Gene_expression (levels) of IL-5 in granulocytes associated with rhinitis
4) Confidence 0.25 Published 2008 Journal Cases J Section Body Doc Link PMC2596115 Disease Relevance 0.90 Pain Relevance 0.23
Furthermore, those with increased proportions of CD25+FoxP3+ cells had decreased antigen-driven production of IL-5 and lower eosinophil counts.
Negative_regulation (decreased) of Gene_expression (production) of IL-5 in eosinophil
5) Confidence 0.25 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.22 Pain Relevance 0
Previous studies have demonstrated lower eosinophil counts, decreased production of IL-5, and increased production of interferon gamma in patients with S. stercoralis and HTLV-1 co-infection [10].
Negative_regulation (decreased) of Gene_expression (production) of IL-5 in eosinophil associated with infection
6) Confidence 0.25 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.36 Pain Relevance 0
This defect in immune host response is associated with lower eosinophil counts and decreased antigen-driven production of IL-5.
Negative_regulation (decreased) of Gene_expression (production) of IL-5 in eosinophil
7) Confidence 0.25 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.72 Pain Relevance 0
Suplatast tosilate is an oral agent that has been shown to inhibit the synthesis of both IL-4 and IL-5.11 Suplatast has been shown in early clinical trials to decrease serum IgE and peripheral blood eosinophil counts.12 Suplatast has also been shown to improve traditional asthma outcomes and decrease airway inflammation.13 However, this molecule has to be used in a three times per day regimen making its utility somewhat problematic since compliance would clearly be an issue.


Negative_regulation (decrease) of Gene_expression (synthesis) of IL-5 in eosinophil associated with asthma and inflammation
8) Confidence 0.14 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.60 Pain Relevance 0.05
In contrast, high-doses of montelukast reduce IL-4, IL-5 and IL-13 levels in the lung and IL-4 and IL-5 expression in BAL [39].
Negative_regulation (reduce) of Gene_expression (expression) of IL-5 in lung
9) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.81 Pain Relevance 0.42
In vitro cyclosporin A inhibit allergen-driven T-cell proliferation, production of IL-2, IL-4, and IL-5 by human CD4+ helper T cells, and IL-5 production in PBMCs from allergen-sensitized atopic asthmatic individuals at physiologic concentrations.
Negative_regulation (inhibit) of Gene_expression (production) of IL-5 in helper T cells associated with asthma
10) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.83 Pain Relevance 0.24
In vitro cyclosporin A inhibit allergen-driven T-cell proliferation, production of IL-2, IL-4, and IL-5 by human CD4+ helper T cells, and IL-5 production in PBMCs from allergen-sensitized atopic asthmatic individuals at physiologic concentrations.
Negative_regulation (inhibit) of Gene_expression (production) of IL-5 in helper T cells associated with asthma
11) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.82 Pain Relevance 0.24
In contrast to GCS subjects, prednisolone failed to suppress IL-4 and IL-5 expression in the GCR subjects.
Neg (failed) Negative_regulation (suppress) of Gene_expression (expression) of IL-5
12) Confidence 0.11 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.60 Pain Relevance 0.11
Accordingly, a previous report demonstrated that administration of the antioxidant thiol N-acetyl-L-cysteine or glutathione to human T cells in culture downregulated the Th2 polarization, with decrease in the expression of IL-4 and IL-5 and simultaneous skewing towards a Th1-type phenotype [78].
Negative_regulation (decrease) of Gene_expression (expression) of IL-5 in T cells
13) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.65 Pain Relevance 0.10
Both beclomethasone and fluticasone inhibit allergen-induced peripheral blood T-cell proliferation and their expression of IL-5 and GM-CSF in asthmatics [18].
Negative_regulation (inhibit) of Gene_expression (expression) of IL-5 in blood associated with occupational lung diseases
14) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.42 Pain Relevance 0.09
In an animal model of asthma intratracheally delivered AP-1 decoy oligodeoxynucleotides attenuate eosinophilic airway inflammation, airway hyperresponsiveness, mucous cell hyperplasia, production of allergen-specific immunoglobulins, and synthesis of IL-4, IL-5, and IL-13 in the lung [111].


Negative_regulation (attenuate) of in mucous cell Gene_expression (synthesis) of IL-5 in lung associated with asthma, rhinitis, inflammation and hyperplasia
15) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.31 Pain Relevance 0.09
In addition, in an uncontrolled study, in asthmatic patients, regular treatment with low doses of theohylline reduced sputum eosinophils and IL-5 expression, but not sputum CD4+ T lymphocytes and IFN-?
Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of IL-5 in sputum associated with asthma
16) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.97 Pain Relevance 0.08
In contrast, high-doses of montelukast reduce IL-4, IL-5 and IL-13 levels in the lung and IL-4 and IL-5 expression in BAL [39].
Negative_regulation (reduce) of Gene_expression (levels) of IL-5 in lung
17) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.80 Pain Relevance 0.42
In vitro, high concentrations of theophylline suppress CD4+ expression of both Th1 and Th2, excluding IL-5, cytokines probably via inhibition of phosphodiesterases [33,34].
Negative_regulation (suppress) of Gene_expression (expression) of IL-5 associated with cytokine
18) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.56 Pain Relevance 0.27
Additionally, the BTPs show inhibition of IL-4, IL-5, IL-8, and CCL11 production [150,151].
Negative_regulation (inhibition) of Gene_expression (production) of IL-5
19) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.28 Pain Relevance 0.16
, GM-CSF, IL-3, IL-4, IL-5, IL-8, prostaglandins, nitric oxide), inhibition of lymphocyte proliferation, inhibition of inflammatory cell migration, and induction of apoptosis in thymocytes.
Negative_regulation (inhibition) of Gene_expression (induction) of IL-5 in thymocytes associated with inflammation and apoptosis
20) Confidence 0.03 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 0.83 Pain Relevance 0.56

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