INT19439

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Context Info
Confidence 0.47
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.50
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1d) signal transducer activity (Htr1d)
Htr1d (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sumatriptan 52 99.98 Very High Very High Very High
Periaqueductal grey 55 99.96 Very High Very High Very High
agonist 17 97.44 Very High Very High Very High
GABAergic 27 76.76 Quite High
Serotonin 5 74.40 Quite High
Raphe 3 69.80 Quite High
antagonist 14 56.16 Quite High
midbrain 9 50.00 Quite Low
Ventral tegmentum 1 34.60 Quite Low
Morphine 1 31.20 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 55 99.96 Very High Very High Very High
Schizophrenia 21 97.84 Very High Very High Very High
Suicidal Behaviour 6 97.52 Very High Very High Very High
Pathologic Processes 3 80.56 Quite High
Congenital Anomalies 3 68.64 Quite High
Headache 10 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Vomiting 2 5.00 Very Low Very Low Very Low
Photophobia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These compounds have high affinity for 5-HT1A and 5-HT1D receptors.
5-HT1D Binding (affinity) of
1) Confidence 0.47 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2060601 Disease Relevance 0 Pain Relevance 0.14
While previous experiments in rat using autoradiography and in situ hybridization have demonstrated the presence of 5-HT1A and 5-HT1B receptors in PAG, 5-HT1D receptor binding or mRNA was undetectable [21,22,25].
5-HT1D Binding (binding) of associated with periaqueductal grey
2) Confidence 0.35 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.29 Pain Relevance 0.49
There was decrease in [3H]sumatriptan binding to the serotonin1D, but not serotonin1F, receptors across all cortical binding layers in rats treated with haloperidol.
serotonin1D Binding (binding) of associated with sumatriptan
3) Confidence 0.15 Published 2006 Journal Schizophr. Res. Section Abstract Doc Link 16916599 Disease Relevance 0.73 Pain Relevance 0.30
There were no significant differences in [3H]sumatriptan binding to the serotonin1D or serotonin1F receptor in Brodmann's area 9 from subjects with schizophrenia.
serotonin1D Binding (binding) of associated with sumatriptan and schizophrenia
4) Confidence 0.15 Published 2006 Journal Schizophr. Res. Section Abstract Doc Link 16916599 Disease Relevance 0.72 Pain Relevance 0.30
There was a significant increase in [3H]sumatriptan binding to the serotonin1D in binding Layer 2 from subjects who had potentially died by suicide that was not present in other binding layers or for the serotonin1F or serotonin7 receptors.
serotonin1D Binding (binding) of associated with sumatriptan and suicidal behaviour
5) Confidence 0.13 Published 2006 Journal Schizophr. Res. Section Abstract Doc Link 16916599 Disease Relevance 0.76 Pain Relevance 0.31

General Comments

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