INT194408

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CALCA, DCLK3) cytoplasm (CALCA, DCLK3) extracellular space (CALCA)
aging (CALCA) extracellular region (CALCA) intracellular (CALCA)
CALCA (Homo sapiens)
DCLK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 392 100.00 Very High Very High Very High
Potency 28 100.00 Very High Very High Very High
Neuropeptide 60 98.68 Very High Very High Very High
agonist 22 95.36 Very High Very High Very High
antagonist 20 25.36 Quite Low
Migraine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 11.88 Low Low
Disease 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Heart Disease 2 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Migraine Disorders 2 5.00 Very Low Very Low Very Low
Reperfusion Injury 2 5.00 Very Low Very Low Very Low
Stroke 2 5.00 Very Low Very Low Very Low
Heat Stress Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, this explanation for changes in CGRP binding affinity with no differences in potency for mutant versus wild type CLR supports the concept of two distinct neuropeptide domains responsible for receptor binding and agonism [31].
Regulation (changes) of CGRP Neg (no) Binding (affinity) of CLR associated with neuropeptide, potency and calcitonin gene-related peptide
1) Confidence 0.15 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.89
In summary, we have characterized specific leucine residues on the CLR membrane protein that participate in the high affinity CGRP binding mediated by the C-terminal phenylalaninamide of the neuropeptide.
Regulation (participate) of CGRP Binding (binding) of CLR associated with neuropeptide and calcitonin gene-related peptide
2) Confidence 0.09 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.40

General Comments

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