INT194409

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
CALCA (Homo sapiens)
IGKV1D-8 (Homo sapiens)
IGKV1D-8 - L24A (4)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 980 100.00 Very High Very High Very High
Neuropeptide 150 77.68 Quite High
Potency 70 21.20 Low Low
agonist 55 8.88 Low Low
antagonist 50 5.00 Very Low Very Low Very Low
Migraine 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 15 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 10 5.00 Very Low Very Low Very Low
Heart Disease 5 5.00 Very Low Very Low Very Low
Neuroblastoma 5 5.00 Very Low Very Low Very Low
Hypertension 5 5.00 Very Low Very Low Very Low
Migraine Disorders 5 5.00 Very Low Very Low Very Low
Reperfusion Injury 5 5.00 Very Low Very Low Very Low
Stroke 5 5.00 Very Low Very Low Very Low
Heat Stress Disorders 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, this affinity loss was no different from wild type receptor when CGRP(1–36) or CGRP(1–19) were used to compete for specific L24A, L34A or L24A,L34A mutant CLR binding sites on transiently transfected HEK293T-RAMP1 cells.
CGRP Binding (compete) of L24A (L24A) associated with calcitonin gene-related peptide
1) Confidence 0.15 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.55
However, this affinity loss was no different from wild type receptor when CGRP(1–36) or CGRP(1–19) were used to compete for specific L24A, L34A or L24A,L34A mutant CLR binding sites on transiently transfected HEK293T-RAMP1 cells.
CGRP Binding (compete) of L24A (L24A) associated with calcitonin gene-related peptide
2) Confidence 0.15 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.55
Therefore, compared to wild type CLR, binding affinity losses of these peptide ligands for the leucine CLR mutations suggests that L24 and L34 are significant binding contacts with CGRP-F37.
CGRP-F37 Binding (contacts) of L24 associated with calcitonin gene-related peptide
3) Confidence 0.15 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.66
However, this affinity loss was no different from wild type receptor when CGRP(1–36) or CGRP(1–19) were used to compete for specific L24A, L34A or L24A,L34A mutant CLR binding sites on transiently transfected HEK293T-RAMP1 cells.
CGRP Binding (compete) of L24A (L24A) associated with calcitonin gene-related peptide
4) Confidence 0.13 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.54
However, this affinity loss was no different from wild type receptor when CGRP(1–36) or CGRP(1–19) were used to compete for specific L24A, L34A or L24A,L34A mutant CLR binding sites on transiently transfected HEK293T-RAMP1 cells.
CGRP Binding (compete) of L24A (L24A) associated with calcitonin gene-related peptide
5) Confidence 0.13 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.54

General Comments

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