INT194413

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (RAMP1) extracellular space (RAMP1) plasma membrane (RAMP1)
RAMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 60 99.98 Very High Very High Very High
Calcitonin gene-related peptide 392 98.00 Very High Very High Very High
agonist 22 88.64 High High
antagonist 20 80.80 Quite High
Potency 28 42.64 Quite Low
Migraine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 67.32 Quite High
Disease 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Heart Disease 2 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Migraine Disorders 2 5.00 Very Low Very Low Very Low
Reperfusion Injury 2 5.00 Very Low Very Low Very Low
Stroke 2 5.00 Very Low Very Low Very Low
Heat Stress Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is plausible that the complex high-affinity receptor binding contacts for CGRP-F37 include not only leucine 24 and 34 on the N-terminal domain of the CLR, but also extracellular residues of RAMP1.
Positive_regulation (residues) of RAMP1 associated with calcitonin gene-related peptide
1) Confidence 0.36 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0.07 Pain Relevance 0.52
Neuropeptide activation of endogenously expressed CLR-RAMP1 heterodimers has been shown to generate increases in cAMP [9].
Positive_regulation (activation) of RAMP1 associated with neuropeptide
2) Confidence 0.33 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.55

General Comments

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