INT194417

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DCLK3) cytoplasm (DCLK3)
DCLK3 (Homo sapiens)
DCLK3 - L34A (1)
Pain Link Frequency Relevance Heat
Neuropeptide 90 98.96 Very High Very High Very High
Calcitonin gene-related peptide 588 98.86 Very High Very High Very High
Potency 42 98.00 Very High Very High Very High
antagonist 30 66.08 Quite High
agonist 33 48.60 Quite Low
Migraine 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 9 23.52 Low Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Heart Disease 3 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Hypertension 3 5.00 Very Low Very Low Very Low
Migraine Disorders 3 5.00 Very Low Very Low Very Low
Reperfusion Injury 3 5.00 Very Low Very Low Very Low
Stroke 3 5.00 Very Low Very Low Very Low
Heat Stress Disorders 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, a purified CLR N-terminal domain overexpressed in E. coli was able to specifically bind 125I-CGRP and could displace this same radiolabeled peptide from a membrane preparation containing native CGRP receptors [25].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CLR associated with calcitonin gene-related peptide
1) Confidence 0.29 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.32
Furthermore, increasing amounts of CGRP(1–36) were also used on HEK293T-RAMP1 cells transiently transfected with L24A, L34A or the L24A,L34A CLR double mutant (Fig 4B).
Positive_regulation (transfected) of Gene_expression (transfected) of CLR (L34A) associated with calcitonin gene-related peptide
2) Confidence 0.21 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.63
CLR negative HEK293T cells stably transfected with RAMP1 were propagated in DMEM plus 10% FBS under standard cell culture conditions.
Positive_regulation (transfected) of Gene_expression (transfected) of CLR
3) Confidence 0.18 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0

General Comments

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