INT194429

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
face 1
IGKV1D-8 (Homo sapiens)
IGKV1D-8 - L24A (2)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 784 99.40 Very High Very High Very High
Neuropeptide 120 75.84 Quite High
antagonist 40 47.20 Quite Low
agonist 44 41.60 Quite Low
Potency 56 21.20 Low Low
Migraine 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 4 33.72 Quite Low
Disease 12 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Heart Disease 4 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low
Migraine Disorders 4 5.00 Very Low Very Low Very Low
Reperfusion Injury 4 5.00 Very Low Very Low Very Low
Stroke 4 5.00 Very Low Very Low Very Low
Heat Stress Disorders 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, this affinity loss was no different from wild type receptor when CGRP(1–36) or CGRP(1–19) were used to compete for specific L24A, L34A or L24A,L34A mutant CLR binding sites on transiently transfected HEK293T-RAMP1 cells.
L24A (L24A) Binding (binding) of associated with calcitonin gene-related peptide
1) Confidence 0.15 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.49
However, this affinity loss was no different from wild type receptor when CGRP(1–36) or CGRP(1–19) were used to compete for specific L24A, L34A or L24A,L34A mutant CLR binding sites on transiently transfected HEK293T-RAMP1 cells.
L24A (L24A) Binding (binding) of associated with calcitonin gene-related peptide
2) Confidence 0.15 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.49
Therefore, compared to wild type CLR, binding affinity losses of these peptide ligands for the leucine CLR mutations suggests that L24 and L34 are significant binding contacts with CGRP-F37.
L24 Binding (binding) of associated with calcitonin gene-related peptide
3) Confidence 0.14 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.65
We propose that L34 and the adjacent negatively charged helical face of the CLR N-terminus domain interacts with this extracellular region of RAMP1 to form a complex high affinity binding pocket that includes L24 of the receptor.
L24 Binding (interacts) of in face
4) Confidence 0.13 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.24

General Comments

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