INT194461

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.46
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
embryos 1
macrophages 1
Chol1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 30 99.50 Very High Very High Very High
withdrawal 9 98.16 Very High Very High Very High
psoriasis 126 91.72 High High
cOX1 2 88.80 High High
cINOD 42 78.12 Quite High
COX-2 inhibitor 52 77.20 Quite High
Inflammation 74 75.72 Quite High
Pain 13 75.04 Quite High
Arthritis 8 74.84 Quite High
cytokine 18 58.36 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 114 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 99.30 Very High Very High Very High
Wound Healing 2 99.28 Very High Very High Very High
Atherosclerosis 60 97.32 Very High Very High Very High
Obesity 52 97.08 Very High Very High Very High
Atherosclerotic Plaque 12 95.76 Very High Very High Very High
Psoriasis 212 95.40 Very High Very High Very High
Cancer 8 92.28 High High
Hyperlipidemia 30 88.24 High High
Myocardial Infarction 47 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
T+294C SNP is associated with elevated plasma LDL cholesterol and apoB levels in men and we show in this work that similar associations are operating in women, we also looked for a potential gene-to-gene interaction between PPAR?
Positive_regulation (elevated) of cholesterol in plasma
1) Confidence 0.67 Published 2006 Journal International Journal of Medical Sciences Section Body Doc Link PMC1525216 Disease Relevance 0.64 Pain Relevance 0.03
Cholesterol sulfotransferase activity was also induced during the culture of epidermal tissues isolated from 13.5-days, postcoitus mouse embryos with a time course that paralleled in vitro stratification [58].
Positive_regulation (induced) of Cholesterol in embryos
2) Confidence 0.67 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0
Cholesterol sulfotransferase activity was also elevated during epidermal wound healing [62].
Positive_regulation (elevated) of Cholesterol associated with wound healing
3) Confidence 0.67 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.19 Pain Relevance 0
Our data demonstrate that pharmacological inhibition of COX reduces expression of the cholesterol-metabolizing enzyme cholesterol 27-hydroxylase and the cholesterol transport protein ABCA1.
Positive_regulation (metabolizing) of cholesterol
4) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.37 Pain Relevance 0.17
Our data demonstrate that pharmacological inhibition of COX reduces expression of the cholesterol-metabolizing enzyme cholesterol 27-hydroxylase and the cholesterol transport protein ABCA1.
Positive_regulation (metabolizing) of cholesterol
5) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.37 Pain Relevance 0.17
The reverse cholesterol transport proteins cholesterol 27-hydroxylase and ATP-binding cassette transporter A1 (ABCA1) export cholesterol from macrophages.
Positive_regulation (proteins) of cholesterol in macrophages
6) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.65 Pain Relevance 0.44
Our data demonstrate that pharmacological inhibition of COX reduces expression of the cholesterol-metabolizing enzyme cholesterol 27-hydroxylase and the cholesterol transport protein ABCA1.
Positive_regulation (enzyme) of cholesterol
7) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.36 Pain Relevance 0.17
agonist GW501516 resulted in an increase of high-density lipoprotein cholesterol (HDL) levels and a decrease of plasma triglycerides 5.
Positive_regulation (increase) of cholesterol in plasma associated with agonist and disorder of lipid metabolism
8) Confidence 0.45 Published 2006 Journal International Journal of Medical Sciences Section Body Doc Link PMC1525216 Disease Relevance 0.50 Pain Relevance 0.05
The latter is a key intermediate in cholesterol synthesis and aids in decreasing LDL cholesterol and increasing HDL cholesterol levels [239, 240].
Positive_regulation (increasing) of cholesterol associated with acquired immune deficiency syndrome or hiv infection and disorder of lipid metabolism
9) Confidence 0.45 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.49 Pain Relevance 0
Retinoids have the most potent activity on increasing the levels of triglycerides, total cholesterol, LDL cholesterol, and VLDL cholesterol and simultaneously decreasing the HDL fraction [137–140].
Positive_regulation (increasing) of cholesterol associated with disorder of lipid metabolism
10) Confidence 0.45 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.38 Pain Relevance 0.17
Retinoids have the most potent activity on increasing the levels of triglycerides, total cholesterol, LDL cholesterol, and VLDL cholesterol and simultaneously decreasing the HDL fraction [137–140].
Positive_regulation (increasing) of cholesterol associated with disorder of lipid metabolism
11) Confidence 0.45 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.39 Pain Relevance 0.17
A much greater effect (relative to controls) was obtained when CholAB was added immediately after FGF2 withdrawal for 2 days, as control cells under those conditions exit the cell cycle [34], [35] whereas CholAB – treated cultures increased in cell density (Figure 4b,c).
Positive_regulation (increased) of CholAB associated with withdrawal
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0 Pain Relevance 0.08

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