INT194462

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 94
Total Number 97
Disease Relevance 68.33
Pain Relevance 12.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
liver 2
corpus callosum 1
bone marrow 1
nucleus 1
Galea 1
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 219 100.00 Very High Very High Very High
agonist 1438 99.92 Very High Very High Very High
cytokine 500 99.92 Very High Very High Very High
antagonist 110 99.84 Very High Very High Very High
Inflammation 1756 99.60 Very High Very High Very High
Multiple sclerosis 165 98.80 Very High Very High Very High
dexamethasone 85 96.92 Very High Very High Very High
Central nervous system 179 96.64 Very High Very High Very High
COX2 124 96.44 Very High Very High Very High
ischemia 93 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2621 100.00 Very High Very High Very High
Shock 1376 100.00 Very High Very High Very High
Stress 495 99.92 Very High Very High Very High
Skin Cancer 103 99.86 Very High Very High Very High
Targeted Disruption 616 99.84 Very High Very High Very High
INFLAMMATION 2019 99.60 Very High Very High Very High
Toxicity 170 99.56 Very High Very High Very High
Sprains And Strains 147 99.52 Very High Very High Very High
Injury 229 99.28 Very High Very High Very High
Diabetes Mellitus 390 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
increase the production and the nuclear localization of the PPAR?
Localization (localization) of PPAR
1) Confidence 0.78 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.15 Pain Relevance 0.04
Using the same paradigm, an examination of several recent publications, summarized in Table 2, reveals inconsistent results between PPAR?
Localization (results) of PPAR
2) Confidence 0.75 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.10 Pain Relevance 0.20
An examination of the full spectrum of PPAR?
Localization (spectrum) of PPAR
3) Confidence 0.75 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.31 Pain Relevance 0.34
However, interpretation of PPAR?
Localization (interpretation) of PPAR
4) Confidence 0.75 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.55 Pain Relevance 0
knockout mice to investigate the importance of PPAR?
Spec (investigate) Localization (importance) of PPAR associated with targeted disruption
5) Confidence 0.75 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.60 Pain Relevance 0
influencing the IGF/IGF-binding protein response to feeding, particularly in males, and suggested that gender differences in the IGF system contribute to the PPAR?
Localization (contribute) of PPAR
6) Confidence 0.75 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.90 Pain Relevance 0.06
These p160 family members are among the coactivators considered important for nuclear receptor function, but the in vivo results indicate their redundancy at least for PPAR?
Localization (redundancy) of PPAR
7) Confidence 0.75 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.13 Pain Relevance 0
activity in bone marrow derived cells, because in these reciprocal transplantation experiments the PPAR?
Localization (because) of PPAR in bone marrow
8) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.01 Pain Relevance 0.03
For preparation of tumor lysates from PPAR?
Localization (preparation) of PPAR associated with cancer
9) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.41 Pain Relevance 0.23
For neutralizing antibody experiments the A4.1 anti-TSP-1 monoclonal antibody (Lab Vision, Fremont, CA) (CSVTCG/CD36) or control antibody (IgM) at 50 µg/mouse were administered intraperitoneally daily to PPAR?
Localization (administered) of PPAR
10) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.70 Pain Relevance 0
Oral administration of PPAR?
Localization (administration) of PPAR
11) Confidence 0.73 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 1.13 Pain Relevance 0.46
administration of PPAR?
Localization (administration) of PPAR
12) Confidence 0.72 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 1.68 Pain Relevance 0.33
types [28], it is more difficult to envisage a broad applicability of PPAR
Localization (applicability) of PPAR
13) Confidence 0.72 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.93 Pain Relevance 0.21
effect of candidates are dependent on the retention of SRC-1 by the GST-PPAR
Localization (retention) of GST-PPAR
14) Confidence 0.71 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0
The physiological role of PIAS1 is to facilitate the localization of PPAR-?
Localization (localization) of PPAR
15) Confidence 0.71 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.18 Pain Relevance 0.12
belongs to the type II nuclear receptor family and like the other two PPAR isotypes, is localized in the nucleus.
Localization (localized) of PPAR in nucleus
16) Confidence 0.70 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.08 Pain Relevance 0
-null strains indicating that in the absence of PPAR?
Neg (absence) Localization (absence) of PPAR associated with sprains and strains
17) Confidence 0.70 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 1.10 Pain Relevance 0
and we still understand little on the binding selectivity of the three PPAR
Localization (selectivity) of PPAR
18) Confidence 0.69 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0.06 Pain Relevance 0
Administration of PPAR?
Localization (Administration) of PPAR
19) Confidence 0.69 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.22 Pain Relevance 0.46
suggests the use of peroxisome proliferator-activated receptor (PPAR) agonists
Localization (use) of PPAR associated with agonist
20) Confidence 0.68 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 2.46 Pain Relevance 0.59

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