INT194465

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 27
Total Number 55
Disease Relevance 31.36
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) plasma membrane (Ldlr)
lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
liver 10
adipocytes 6
body 4
hepatocytes 3
microglia 3
Ldlr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 450 99.60 Very High Very High Very High
Bile 203 93.72 High High
Catecholamine 108 93.44 High High
noradrenaline 126 85.44 High High
metalloproteinase 32 79.28 Quite High
antagonist 12 77.96 Quite High
cytokine 52 74.52 Quite High
Hippocampus 15 69.76 Quite High
behavioral therapy 14 69.12 Quite High
Inflammatory response 45 67.16 Quite High
Disease Link Frequency Relevance Heat
Infection 354 100.00 Very High Very High Very High
Cytomegalovirus Infection 197 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 169 100.00 Very High Very High Very High
Hypertriglyceridemia 28 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 1077 99.90 Very High Very High Very High
Obesity 826 99.88 Very High Very High Very High
Hyperlipoproteinemia Type Ii 1849 99.80 Very High Very High Very High
Disease 495 99.68 Very High Very High Very High
INFLAMMATION 379 99.60 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

75 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite this, we found that apoB100-LDL signaling through the LDLR altered gene expression of several genes whereof two in the PKA complex (Fig. 1G).
Gene_expression (expression) of LDLR
1) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.42 Pain Relevance 0.15
Since the LDL receptor (LDLR) is expressed on adipocytes [8], we investigated its role in the interaction between apoB100 lipoproteins and adipocytes by analyzing apoB100-only mice that expressed the LDLR (Ldlr+/+Apob100/100) or were LDLR-deficient (Ldlr?
Gene_expression (expressed) of LDLR in adipocytes associated with obesity
2) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.69 Pain Relevance 0.15
Since the LDL receptor (LDLR) is expressed on adipocytes [8], we investigated its role in the interaction between apoB100 lipoproteins and adipocytes by analyzing apoB100-only mice that expressed the LDLR (Ldlr+/+Apob100/100) or were LDLR-deficient (Ldlr?
Gene_expression (expressed) of LDL receptor in adipocytes associated with obesity
3) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.69 Pain Relevance 0.15
Since the LDL receptor (LDLR) is expressed on adipocytes [8], we investigated its role in the interaction between apoB100 lipoproteins and adipocytes by analyzing apoB100-only mice that expressed the LDLR (Ldlr+/+Apob100/100) or were LDLR-deficient (Ldlr?
Gene_expression (expressed) of LDLR in adipocytes associated with obesity
4) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.73 Pain Relevance 0.14
Since the LDL receptor (LDLR) is expressed on adipocytes [8], we investigated its role in the interaction between apoB100 lipoproteins and adipocytes by analyzing apoB100-only mice that expressed the LDLR (Ldlr+/+Apob100/100) or were LDLR-deficient (Ldlr?
Gene_expression (expressed) of Ldlr in adipocytes associated with obesity
5) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.79 Pain Relevance 0.14
Our findings suggest that decreased LDL concentrations in the microcirculation of adipose tissue cause a reciprocal activation of lipolysis in white adipose tissue when apoB100-LDL levels are decreased.
Gene_expression (levels) of apoB100-LDL in adipose tissue associated with obesity
6) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.85 Pain Relevance 0.11
Since the LDL receptor (LDLR) is expressed on adipocytes [8], we investigated its role in the interaction between apoB100 lipoproteins and adipocytes by analyzing apoB100-only mice that expressed the LDLR (Ldlr+/+Apob100/100) or were LDLR-deficient (Ldlr?
Gene_expression (expressed) of LDLR-deficient in adipocytes associated with obesity
7) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.79 Pain Relevance 0.14
Despite this, we found that apoB100-LDL signaling through the LDLR altered gene expression of several genes whereof two in the PKA complex (Fig. 1G).
Gene_expression (signaling) of apoB100-LDL
8) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.42 Pain Relevance 0.15
To date, IDLVs have not been used for LDLR gene transfer and FH gene therapy.
Gene_expression (transfer) of LDLR gene associated with hyperlipoproteinemia type ii
9) Confidence 0.61 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.39 Pain Relevance 0
In addition, a sensitive non-invasive method using a scintillation camera is available to determine the location, magnitude, and duration of LDLR transgene expression which could provide functional transgene expression in gene therapy trials of FH [74].
Gene_expression (expression) of LDLR associated with hyperlipoproteinemia type ii
10) Confidence 0.61 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.89 Pain Relevance 0
Similarly, injection of a replication-defective Ad encoding the hLDLR driven by an optimised CMV promoter into the portal vein of WHHL rabbits, resulted in over-expression of hLDLR in the majority of hepatocytes that exceeded the levels in normal human liver by at least 10 fold.
Gene_expression (over) of hLDLR in liver associated with cytomegalovirus infection
11) Confidence 0.61 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.57 Pain Relevance 0
After successful re-infusion of transduced cells through a catheter placed in the inferior mesenteric vein at the time of liver resection, only low-level expression of the transferred LDLR gene was observed in the five patients enrolled in the trial.
Gene_expression (expression) of LDLR gene in liver
12) Confidence 0.61 Published 2010 Journal Int Arch Med Section Abstract Doc Link PMC3016243 Disease Relevance 0.91 Pain Relevance 0
This vector construct was able to mediate LDLR expression at significant levels in the CHOldlA7 cells and in human fibroblasts derived from FH patients for 3 months and to retain the classical expression regulation by sterol levels in these cells.
Gene_expression (expression) of LDLR in fibroblasts associated with hyperlipoproteinemia type ii
13) Confidence 0.61 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.34 Pain Relevance 0
While LDLR is expressed by the majority of body cells, hepatic reconstitution of LDLR expression alone may be sufficient for metabolic correction [71,72].
Gene_expression (expressed) of LDLR in body
14) Confidence 0.61 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.90 Pain Relevance 0
In vivo injection of 1 × 109 infectious virus particles into the portal vein of WHHL rabbits resulted in liver-specific expression of the LDLR and clinical chemistry and histological analyses showed normal liver function and morphology during the 2-year follow-up without safety issues.
Spec (analyses) Gene_expression (expression) of LDLR in portal vein
15) Confidence 0.61 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.41 Pain Relevance 0
However, the high level of LDLR expression and substantial reduction of total and LDL cholesterol achieved by adenovirus LDLR gene transfer in these animal models led to a massive intracellular lipid (cholesterol and cholesterol ester) deposition in transduced cells [130,133].
Gene_expression (expression) of LDLR
16) Confidence 0.61 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.45 Pain Relevance 0
Recombinant derived LDLR mRNA was detected in liver cells for 6 months.
Gene_expression (detected) of LDLR mRNA in liver
17) Confidence 0.61 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.40 Pain Relevance 0
Liver biopsies performed four months after treatment revealed LDLR transgene expression in a limited number of hepatocytes by in situ hybridisation in all four subjects.
Gene_expression (expression) of LDLR in hepatocytes
18) Confidence 0.61 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.35 Pain Relevance 0
Kinetic studies of the LDL metabolism demonstrated that LDL catabolism was increased in the same patient, which was consistent with increased LDLR expression [121].
Gene_expression (expression) of LDLR
19) Confidence 0.61 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.20 Pain Relevance 0
While LDLR is expressed by the majority of body cells, hepatic reconstitution of LDLR expression alone may be sufficient for metabolic correction [71,72].
Gene_expression (expression) of LDLR in body
20) Confidence 0.61 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.86 Pain Relevance 0

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