INT194466

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.27
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
Apo (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 8 72.24 Quite High
agonist 33 67.24 Quite High
anesthesia 2 56.56 Quite High
Catecholamine 12 18.64 Low Low
Inflammation 18 17.36 Low Low
Angina 7 12.88 Low Low
alcohol 22 5.00 Very Low Very Low Very Low
noradrenaline 14 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 611 100.00 Very High Very High Very High
Sprains And Strains 142 99.80 Very High Very High Very High
Hyperlipidemia 15 97.68 Very High Very High Very High
Shock 16 96.84 Very High Very High Very High
Coronary Heart Disease 66 90.16 High High
Atherosclerosis 100 83.60 Quite High
Coronary Artery Disease 50 80.08 Quite High
Obesity 103 75.84 Quite High
Cancer 4 65.84 Quite High
Disease 16 54.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heterozygotes with a 40% decrease in CETP levels had a mean increase in HDL-C of 30% and no significant change in LDL-C levels, while homozygotes with complete loss of CETP levels had a greater than 100% increase in HDL-C and 40% decrease in LDL-C and Apo B levels (Inazu et al 1990; Koizumi et al 1991).
Positive_regulation (increase) of Apo B associated with disorder of lipid metabolism
1) Confidence 0.12 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.07 Pain Relevance 0.04
Expressing 26695 Fur in G27 (the “Fur swap” strain) did not restore apo-Fur sodB regulation in G27 under either iron-limited growth or iron-depletion shock conditions (Fig. 4A and data not shown).
Neg (not) Positive_regulation (restore) of apo associated with shock and sprains and strains
2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671405 Disease Relevance 0.96 Pain Relevance 0
Taken together these data indicate that this nucleotide residue is important for direct apo-Fur binding to the sodB promoter.



Positive_regulation (important) of apo
3) Confidence 0.06 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2671405 Disease Relevance 0.20 Pain Relevance 0
At the highest dosing regimen, Apo AI and Apo E increased by 27% and 66% respectively, while Apo B decreased by 26% (Clark et al 2004).
Positive_regulation (increased) of Apo
4) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.65 Pain Relevance 0
HDL-C and Apo-AI levels increased from baseline over the same time period, but did not reach statistical significance (Figures 1 and 3).
Positive_regulation (increased) of Apo associated with disorder of lipid metabolism
5) Confidence 0.03 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993963 Disease Relevance 0.40 Pain Relevance 0
Littermate wild-type mice (Mttpflox/flox), injected with phosphate-buffered saline, had approximately equal concentrations of plasma apoB100 and apoB48, as shown by western blot analysis, while Apob100/100 mice [7] only had apoB100 in plasma (Fig. 2A).
Positive_regulation (had) of apoB100 in plasma
6) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.17 Pain Relevance 0.06
In a group of 543 healthy, middle-aged men the C genotype was associated with elevated levels of low-density lipoprotein (LDL) cholesterol and apolipoprotein B (Apo B).
Positive_regulation (elevated) of Apo B associated with disorder of lipid metabolism
7) Confidence 0.01 Published 2006 Journal International Journal of Medical Sciences Section Body Doc Link PMC1525216 Disease Relevance 0.83 Pain Relevance 0.03

General Comments

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