INT194475

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.16
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
plasma 1
glial cells 1
Neurons 1
Chol1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 29 90.92 High High
Inflammation 52 68.64 Quite High
agonist 2 62.64 Quite High
psoriasis 63 61.80 Quite High
cytokine 29 48.04 Quite Low
Kinase C 36 5.00 Very Low Very Low Very Low
Hippocampus 21 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
diabetic neuropathy 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 65 100.00 Very High Very High Very High
Vibrio Infection 23 99.64 Very High Very High Very High
Psoriasis 106 96.36 Very High Very High Very High
Atherosclerosis 15 94.96 High High
Obesity 28 85.24 High High
Stress 28 80.68 Quite High
Hyperlipidemia 24 72.76 Quite High
Targeted Disruption 9 69.04 Quite High
INFLAMMATION 58 68.64 Quite High
Disease 220 62.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
T+294C SNP is associated with elevated plasma LDL cholesterol and apoB levels in men and we show in this work that similar associations are operating in women, we also looked for a potential gene-to-gene interaction between PPAR?
cholesterol Binding (associated) of in plasma
1) Confidence 0.36 Published 2006 Journal International Journal of Medical Sciences Section Body Doc Link PMC1525216 Disease Relevance 0.64 Pain Relevance 0.03
Nowadays there is an increased interest in HDL cholesterol, because clinical and epidemiological studies showed an inverse relationship between the level of HDL and the development of atherosclerosis [55].
cholesterol Binding (interest) of associated with atherosclerosis and disorder of lipid metabolism
2) Confidence 0.36 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.22 Pain Relevance 0.09
Neurons and glial cells contain LRP receptors, which are large endocytic membrane receptors that can bind and internalise the ApoE-cholesterol phospholipid complex and then fuse with lysosomes.
cholesterol Binding (bind) of in glial cells
3) Confidence 0.35 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.33 Pain Relevance 0.05
Neurons and glial cells contain LRP receptors, which are large endocytic membrane receptors that can bind and internalise the ApoE-cholesterol phospholipid complex and then fuse with lysosomes.
cholesterol Binding (bind) of in Neurons
4) Confidence 0.12 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.33 Pain Relevance 0.05
Fluorescence-conjugated Cholera toxin B subunit (CholB) recognizes GM1+ gangliosides on lipid rafts and can be used to label cells differentiating towards the neuronal lineage [27], [28], [29].
CholB Binding (recognizes) of in neuronal associated with vibrio infection
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.63 Pain Relevance 0

General Comments

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