INT194479

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Context Info
Confidence 0.81
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 47
Total Number 47
Disease Relevance 30.36
Pain Relevance 6.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
hepatocytes 1
endothelial cells 1
bone marrow 1
fibroblasts 1
Dorsal root ganglion 1
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
Periaqueductal grey 7 100.00 Very High Very High Very High
Kinase C 31 99.98 Very High Very High Very High
antagonist 80 99.84 Very High Very High Very High
agonist 644 99.48 Very High Very High Very High
Inflammation 846 99.44 Very High Very High Very High
cINOD 105 98.16 Very High Very High Very High
Inflammatory stimuli 16 97.40 Very High Very High Very High
Dopamine 3 96.68 Very High Very High Very High
medulla 1 96.04 Very High Very High Very High
cytokine 149 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1812 100.00 Very High Very High Very High
Urological Neuroanatomy 7 100.00 Very High Very High Very High
Obesity 498 99.60 Very High Very High Very High
INFLAMMATION 974 99.44 Very High Very High Very High
Cognitive Disorder 21 99.28 Very High Very High Very High
Colorectal Cancer 55 99.14 Very High Very High Very High
Targeted Disruption 192 98.24 Very High Very High Very High
Brain Injury 29 98.16 Very High Very High Very High
Breast Cancer 65 98.12 Very High Very High Very High
Carcinoma 59 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the role of PPAR?
Phosphorylation (role) of PPAR
1) Confidence 0.81 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.07 Pain Relevance 0
-deficient bone marrow cells, when transplanted into WT hosts, conferred the tumor-suppressing phenotype of PPAR?
Phosphorylation (phenotype) of PPAR in bone marrow associated with cancer
2) Confidence 0.81 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.75 Pain Relevance 0.04
Because TSP-1 can be expressed in several cell types, including tumor cells, endothelial cells and fibroblasts, we next determined the cellular origin for TSP-1 in the tumors of PPAR?
Phosphorylation (tumors) of PPAR in fibroblasts associated with cancer
3) Confidence 0.81 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.38 Pain Relevance 0.20
Statistically calculated mean expression levels of PPAR?
Phosphorylation (levels) of PPAR
4) Confidence 0.80 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.06 Pain Relevance 0
At present, the role of PPAR?
Phosphorylation (role) of PPAR
5) Confidence 0.79 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.88 Pain Relevance 0.06
available data on the pathophysiology of PPARs has been obtained from metabolic
Phosphorylation (pathophysiology) of PPAR
6) Confidence 0.79 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.22 Pain Relevance 0
Phosphorylation of the PPAR?
Phosphorylation (Phosphorylation) of PPAR
7) Confidence 0.78 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0.05
Another study reports that 8% of primary colorectal tumors harbor a loss of function mutation in one allele of the PPAR-?
Phosphorylation (allele) of PPAR associated with colorectal cancer
8) Confidence 0.71 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 1.77 Pain Relevance 0
The use of exogenously administered PPAR-?
Phosphorylation (use) of PPAR
9) Confidence 0.71 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 1.19 Pain Relevance 0.38
These findings suggest the possibility of PPAR-?
Phosphorylation (possibility) of PPAR
10) Confidence 0.71 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.57 Pain Relevance 0.57
and/or PPAR?
Phosphorylation (/) of PPAR
11) Confidence 0.70 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.52 Pain Relevance 0.60
status provides valuable information regarding the effects of PPAR?
Phosphorylation (effects) of PPAR
12) Confidence 0.69 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.18 Pain Relevance 0
ligand-dependent sumoylation of PPAR?
Phosphorylation (sumoylation) of PPAR
13) Confidence 0.69 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266979 Disease Relevance 0.38 Pain Relevance 0.12
-null mice or primary hepatocytes isolated from PPAR?
Phosphorylation (isolated) of PPAR in hepatocytes
14) Confidence 0.66 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.68 Pain Relevance 0.22
evaluating the efficacy of PPAR?
Phosphorylation (efficacy) of PPAR
15) Confidence 0.64 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.28 Pain Relevance 0.16
This PKC phosphorylation of PPAR?
Phosphorylation (phosphorylation) of PPAR associated with kinase c
16) Confidence 0.63 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.21 Pain Relevance 0.31
This insulin-mediated phosphorylation of PPAR?
Phosphorylation (phosphorylation) of PPAR
17) Confidence 0.63 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.19 Pain Relevance 0.09
is believed to play an important role in statin-mediated acute anti-inflammatory effects, though the importance of phosphorylation in PPAR?
Phosphorylation (phosphorylation) of PPAR associated with inflammation
18) Confidence 0.63 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.16 Pain Relevance 0.30
More interestingly, the ADH and/or acute ethanol-induced cardiac contractile and intracellular Ca2+ responses were coordinated with hyperactivated AMPK signaling cascade including phosphorylation of AMPK, ACC and LKB1 as well as downregulation of protein phosphatase PP2A subunit and PPAR-?.
Phosphorylation (phosphorylation) of PPAR
19) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.42 Pain Relevance 0.08
which subsequently phosphorylates and inactivates PPAR?.
Phosphorylation (phosphorylates) of PPAR
20) Confidence 0.61 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.81 Pain Relevance 0.41

General Comments

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