INT19449

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Context Info
Confidence 0.47
First Reported 1988
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 22
Total Number 24
Disease Relevance 7.40
Pain Relevance 4.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FANCB) nucleus (FANCB)
Anatomy Link Frequency
platelet 2
brain 1
T-cell 1
FANCB (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 20 100.00 Very High Very High Very High
backache 9 98.16 Very High Very High Very High
Nerve growth factor 8 96.98 Very High Very High Very High
Angina 3 94.24 High High
Glutamate 63 93.00 High High
Dynorphin 2 92.76 High High
cytokine 20 88.80 High High
ischemia 3 86.04 High High
Opioid 3 85.04 High High
potassium channel 6 84.48 Quite High
Disease Link Frequency Relevance Heat
Hemorrhage 7 99.70 Very High Very High Very High
Cancer 15 98.94 Very High Very High Very High
Pancreatic Cancer 12 98.88 Very High Very High Very High
Age-related Macular Degeneration 328 98.86 Very High Very High Very High
Low Back Pain 9 98.16 Very High Very High Very High
Blindness 12 98.00 Very High Very High Very High
Disease 97 97.88 Very High Very High Very High
Carcinoma 1 97.40 Very High Very High Very High
Cv General 3 Under Development 15 94.24 High High
Autoimmune Disease 39 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ranibizumab (Lucentis®, Genentech, Inc., San Francisco, CA, USA) is a humanized antigen-binding fragment (Fab) that neutralizes all VEGF-A isoforms.
Fab Binding (binding) of
1) Confidence 0.47 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698673 Disease Relevance 0.59 Pain Relevance 0.04
There was no interaction between FAB and chronicity, and FABQ values on day 1 did not predict disability or quality of life at day 15.
FAB Neg (no) Binding (interaction) of
2) Confidence 0.43 Published 2005 Journal Spine Section Body Doc Link 16284579 Disease Relevance 0 Pain Relevance 0
High FAB was associated with sickness absence days 1 year later (relative risk, 1.45, 95% confidence interval = 1.24 to 1.70), controlled for LBP, previous sickness absence, and age.
FAB Binding (associated) of associated with backache
3) Confidence 0.36 Published 2010 Journal J. Occup. Environ. Med. Section Abstract Doc Link 20042878 Disease Relevance 0.71 Pain Relevance 0.68
Comparison of the morphine complex with the structure of the free Fab shows that a domain closure occurs upon binding of the ligand.
Fab Binding (binding) of associated with morphine
4) Confidence 0.36 Published 2004 Journal J. Mol. Biol. Section Abstract Doc Link 15019787 Disease Relevance 0.08 Pain Relevance 0.65
Treatment of age-related macular degeneration: focus on ranibizumab

Ranibizumab, a humanized antigen-binding fragment (Fab) that binds all isoforms of VEGF-A, significantly slows down loss of vision and causes significant visual improvement in many patients with choroidal neovascularization (CNV) due to exudative age-related macular degeneration (AMD).

Fab Binding (binding) of associated with blindness and age-related macular degeneration
5) Confidence 0.35 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Title Doc Link PMC2698673 Disease Relevance 0.65 Pain Relevance 0
Efflux of intracerebral IgG is FcRn-mediated as intracerebral IgG elimination into the systemic circulation is competitively inhibited by Fc fragments, which block the FcRn receptor, but not impeded by Fab fragments, which do not bind to the FcRn receptor [7,8].
Fab Neg (not) Binding (bind) of
6) Confidence 0.35 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2794657 Disease Relevance 0.17 Pain Relevance 0
A computational docking model of the alphaD11 Fab-NGF complex, based on epitope mapping using a pool of 44 NGF mutants and experimentally validated by small-angle X-ray scattering, provided the structural basis for identifying the residues involved in alphaD11 Fab binding.
Fab Binding (binding) of associated with nerve growth factor
7) Confidence 0.35 Published 2008 Journal J. Mol. Biol. Section Abstract Doc Link 18635195 Disease Relevance 0.08 Pain Relevance 0.45
Treatment of age-related macular degeneration: focus on ranibizumab

Ranibizumab, a humanized antigen-binding fragment (Fab) that binds all isoforms of VEGF-A, significantly slows down loss of vision and causes significant visual improvement in many patients with choroidal neovascularization (CNV) due to exudative age-related macular degeneration (AMD).

Fab Binding (binds) of associated with blindness and age-related macular degeneration
8) Confidence 0.35 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Title Doc Link PMC2698673 Disease Relevance 0.66 Pain Relevance 0
Further studies are underway to develop alternative heparin dosing strategies in an effort to reduce the occurrence of bleeding complications associated with c7E3 Fab administration and to assess the benefit of c7E3 Fab-mediated platelet inhibition in lower risk patient subgroups.
Fab Binding (associated) of in platelet associated with hemorrhage
9) Confidence 0.35 Published 1994 Journal J Invasive Cardiol Section Abstract Doc Link 10155090 Disease Relevance 0.54 Pain Relevance 0.15
To develop a T-cell-based therapy for carcinomas, the superantigen staphylococcal enterotoxin A (SEA) was supplied with tumor specificity by means of a recombinant fusion of the Fab fragment of the monoclonal antibody C242 recognizing human colorectal (CRC) and pancreatic carcinomas (PC).
Fab Binding (recognizing) of in T-cell associated with cancer, pancreatic cancer and carcinoma
10) Confidence 0.35 Published 2000 Journal J. Immunother. Section Abstract Doc Link 10687147 Disease Relevance 0.61 Pain Relevance 0
Platelet inhibition occurred within minutes, but m7E3 Fab that did not bind to platelets cleared rapidly from circulation.
Fab Neg (not) Spec (cleared) Binding (bind) of in platelets
11) Confidence 0.31 Published 1995 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 8573549 Disease Relevance 0.48 Pain Relevance 0.06
A similar binding curve could be obtained as that for binding of morphine to an antibody Fab' fragment/polymer layer - indicating that synthetic receptors produced are comparable to those of antibody layers.
Fab Binding (binding) of associated with morphine
12) Confidence 0.17 Published 2008 Journal Biosens Bioelectron Section Abstract Doc Link 18718754 Disease Relevance 0 Pain Relevance 0.36
As a model system, Fab' fragments derived from a purified immunoglobulin G (IgG) antibody were covalently bound to controlled-porosity glass and used as constituents of the analyte-microreactor device.
Fab Binding (bound) of
13) Confidence 0.16 Published 2003 Journal Electrophoresis Section Abstract Doc Link 14613197 Disease Relevance 0.08 Pain Relevance 0.12
OBJECTIVE: To assess the association of fear avoidance beliefs (FAB) with disability and quality of life in elderly Spanish subjects.
FAB Binding (association) of
14) Confidence 0.15 Published 2007 Journal Spine Section Body Doc Link 17762816 Disease Relevance 0 Pain Relevance 0
The interaction between the RF and IgG is well documented; the RF Fab (antigen binding site) recognizes IgG Fc (constant) segment most frequently at the level of C?
Fab Binding (recognizes) of
15) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.88 Pain Relevance 0.22
The interaction between the RF and IgG is well documented; the RF Fab (antigen binding site) recognizes IgG Fc (constant) segment most frequently at the level of C?
Fab Binding (binding) of
16) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.87 Pain Relevance 0.21
Therefore the FabÂ’ is bound to a polyethylene glycol moiety (PEG), which increases its half-life and potentially further decreases its immunogenicity.
Fab Binding (bound) of
17) Confidence 0.06 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673817 Disease Relevance 0.24 Pain Relevance 0.25
At the second assay step, anti-morphine MAbs' Fab' fragments, in which free amino groups were biotinylated by N-hydrosuccinimide-biotin ester, were bound to chemically modified immunosorbent.
Fab Binding (bound) of associated with morphine
18) Confidence 0.06 Published 2004 Journal Hybrid. Hybridomics Section Abstract Doc Link 15000851 Disease Relevance 0.08 Pain Relevance 0.49
Soluble Fab fragments containing the Fc region ligand for Fc receptor binding inhibited A?
Fab Binding (fragments) of
19) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1199616 Disease Relevance 0.37 Pain Relevance 0.15
Catalysis was associated with Fab and single-chain antibody proteins [30].
Fab Binding (associated) of
20) Confidence 0.04 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.32 Pain Relevance 0

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