INT194530

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2008
Negated 3
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 11.78
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
UOX (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 13 84.92 Quite High
headache 24 83.12 Quite High
Arthritis 42 49.32 Quite Low
Inflammation 42 48.92 Quite Low
adenocard 41 38.04 Quite Low
Pain 27 20.44 Low Low
fibrosis 11 13.20 Low Low
Bioavailability 16 5.00 Very Low Very Low Very Low
Onset of action 15 5.00 Very Low Very Low Very Low
pruritus 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tumor Lysis Syndrome 505 99.88 Very High Very High Very High
Sprains And Strains 31 99.88 Very High Very High Very High
Hyperuricemia 457 99.56 Very High Very High Very High
Hypersensitivity 255 98.48 Very High Very High Very High
Apoptosis 22 96.40 Very High Very High Very High
Arthralgia 16 93.96 High High
Urticaria 49 93.36 High High
Crystal Associated Disease 374 92.44 High High
Bronchospasm 28 91.08 High High
Hemolytic Anemia 11 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of needing for dialysis is an advance in comparison with other regimes that do not use rasburicase, whose need is more remarkable. 67
Neg (not) Gene_expression (use) of uricase
1) Confidence 0.65 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.84 Pain Relevance 0
Adverse effects of rasburicase
Gene_expression (effects) of uricase
2) Confidence 0.65 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 1.00 Pain Relevance 0
A modification of a reactive cysteine, obtained during the purification process of non-recombinant urate oxidase, and the higher purity of rasburicase may explain the differences between the old and the new urate oxidase. 12
Gene_expression (purity) of uricase
3) Confidence 0.65 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.74 Pain Relevance 0
This objective has been achieved with the synthesis of uricase.

3.

Gene_expression (synthesis) of uricase
4) Confidence 0.52 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.47 Pain Relevance 0
A genetically modified strain of Saccharomyces cerevisiae expresses urate oxidase cDNA, cloned from a strain of Aspergillus flavus. 23 It allows to obtain urate oxidase more rapidly and in a larger quantity.
Gene_expression (expresses) of urate oxidase associated with sprains and strains
5) Confidence 0.52 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.92 Pain Relevance 0
In eight subjects pUox remained detectable for the full 21-day period of observation.
Gene_expression (detectable) of pUox
6) Confidence 0.51 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526556 Disease Relevance 0.61 Pain Relevance 0
In eight subjects ('long-circulating', Figure 3a), pUox was still measurable at three weeks after injection, whereas in five subjects ('early elimination', Figure 3b) pUox could not be detected beyond day 10 after injection.
Neg (not) Gene_expression (detected) of pUox
7) Confidence 0.51 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526556 Disease Relevance 0 Pain Relevance 0
Before treatment, pUox was undetectable.
Gene_expression (undetectable) of pUox
8) Confidence 0.51 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526556 Disease Relevance 0.22 Pain Relevance 0
In spite of variable pharmacokinetics, in every subject there was a clear inverse relationship between simultaneously measured levels of pUox and pUAc (shown for the 8 mg dose cohort in Figure 1).
Gene_expression (levels) of pUox
9) Confidence 0.45 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526556 Disease Relevance 0.07 Pain Relevance 0
A modification of a reactive cysteine, obtained during the purification process of non-recombinant urate oxidase, and the higher purity of rasburicase may explain the differences between the old and the new urate oxidase. 12
Gene_expression (old) of urate oxidase
10) Confidence 0.45 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.77 Pain Relevance 0
Already before 2002, when Food and Drugs Administration (FDA) of US has approved the use of urate oxidase for the management of paediatric patients at risk for TLS (Tumor Lysis Syndrome) 26, urate oxidase was used for this purpose with good efficacy. 13,14,27-30 Currently US FDA does not approve its use in adult, instead EU FDA has approved it in children and adult. 19
Gene_expression (used) of urate oxidase associated with tumor lysis syndrome
11) Confidence 0.45 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.82 Pain Relevance 0
They reduced plasma uricase activity. 16
Gene_expression (activity.) of uricase in plasma
12) Confidence 0.45 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 1.94 Pain Relevance 0.17
A modification of a reactive cysteine, obtained during the purification process of non-recombinant urate oxidase, and the higher purity of rasburicase may explain the differences between the old and the new urate oxidase. 12
Gene_expression (explain) of urate oxidase
13) Confidence 0.45 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.78 Pain Relevance 0
The first molecule of this kind, synthetized in 1968 and introduced in France since 1975 and in Italy since 1984, was a non-recombinant urate oxidase. 10 It was a natural uricase, obtained from Aspergillus flavus cultures (Uricozyme TM), used to prevent and treat hyperuricemia occurring during chemotherapy. 10
Gene_expression (non) of uricase associated with hyperuricemia
14) Confidence 0.39 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.61 Pain Relevance 0
The first molecule of this kind, synthetized in 1968 and introduced in France since 1975 and in Italy since 1984, was a non-recombinant urate oxidase. 10 It was a natural uricase, obtained from Aspergillus flavus cultures (Uricozyme TM), used to prevent and treat hyperuricemia occurring during chemotherapy. 10
Neg (prevent) Gene_expression (prevent) of uricase associated with hyperuricemia
15) Confidence 0.39 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.73 Pain Relevance 0
After subcutaneous injection of PEG-uricase, pUox increased gradually, suggesting slow absorption into the circulation.
Gene_expression (injection) of pUox
16) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526556 Disease Relevance 0.21 Pain Relevance 0
In 1996, using the recombinant DNA technique, another molecule was obtained from a genetically modified Saccharomyces cerevisiae strain that expresses urate oxidase cDNA, cloned from a strain of A. flavus (Leplatois et al 1992).
Gene_expression (expresses) of urate oxidase associated with sprains and strains
17) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 0.55 Pain Relevance 0
This technology enabled production of a molecule of urate oxidase (rasburicase) characterized by higher purity and higher activity in compared with non-recombinant urate oxidase (Bayol et al 2002).
Gene_expression (production) of urate oxidase
18) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727789 Disease Relevance 0.52 Pain Relevance 0

General Comments

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