INT194532

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.78
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

UOX (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 8 53.84 Quite High
fibrosis 1 29.00 Quite Low
Inflammation 10 26.52 Quite Low
Arthritis 10 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperuricemia 47 99.76 Very High Very High Very High
Aging 3 95.52 Very High Very High Very High
Disease 5 94.52 High High
Crystal Associated Disease 74 89.72 High High
Tumor Lysis Syndrome 31 50.00 Quite Low
General Immunology 2 44.08 Quite Low
Emergencies 2 35.20 Quite Low
Chronic Renal Failure 1 31.16 Quite Low
Fibrosis 1 29.00 Quite Low
Arteriolosclerosis 1 27.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After subcutaneous injection of PEG-uricase, pUox increased gradually, suggesting slow absorption into the circulation.
Positive_regulation (increased) of pUox
1) Confidence 0.35 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526556 Disease Relevance 0.21 Pain Relevance 0
Mice with gene inactivation of urate oxidase have hyperuricemia and renal tubulopathy. 9
Positive_regulation (inactivation) of urate oxidase associated with hyperuricemia
2) Confidence 0.33 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1838823 Disease Relevance 0.37 Pain Relevance 0.03
The time to reach peak pUox (tmax) varied from 2 to 10 days, averaging 7 days.
Positive_regulation (reach) of pUox
3) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526556 Disease Relevance 0.20 Pain Relevance 0

General Comments

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