INT194595

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 9.30
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFSF10) extracellular space (TNFSF10) extracellular region (TNFSF10)
plasma membrane (TNFRSF10B) cell-cell signaling (TNFSF10)
TNFSF10 (Homo sapiens)
TNFRSF10B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 24 92.44 High High
rheumatoid arthritis 35 89.72 High High
Inflammation 91 79.60 Quite High
antagonist 3 75.72 Quite High
cva 1 55.28 Quite High
cINOD 3 47.08 Quite Low
Pain 2 30.80 Quite Low
Arthritis 20 5.00 Very Low Very Low Very Low
Kinase C 10 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 436 100.00 Very High Very High Very High
Death 62 100.00 Very High Very High Very High
Arthritis 50 94.84 High High
Cancer 394 94.24 High High
Necrosis 10 91.00 High High
Rheumatoid Arthritis 35 89.72 High High
Colon Cancer 132 83.48 Quite High
Diabetes Mellitus 83 81.96 Quite High
Toxicity 14 80.64 Quite High
Synovitis 8 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRAIL induces apoptosis by binding and cross-linking the death-domain containing receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) [3].
TRAIL Binding (binding) of DR5 associated with apoptosis and death
1) Confidence 0.15 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.16 Pain Relevance 0.17
TRAIL is a member of the TNF family of ligands, able to induce cell death [18] through association with the death-domain containing receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) [19,20].
TRAIL Binding (association) of DR5 associated with death
2) Confidence 0.15 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.53 Pain Relevance 0.08
TRAIL initiates apoptosis by binding to two death receptors, DR4 and DR5, while binding to the decoy receptors which lack the death domain, such as DCR1, DCR2 and osteoprotegerin, inhibits its pro-apoptotic activity [9].
TRAIL Binding (binding) of DR5 associated with apoptosis and death
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.68 Pain Relevance 0.07
When TRAIL binds TRAIL-R1 (DR4) and TRAIL-R2 (DR5) apoptotic signals are transduced.
TRAIL Binding (binds) of DR5 associated with apoptosis
4) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.64 Pain Relevance 0.11
Binding of TRAIL to the death inducing receptors DR4/DR5 results in the recruitment of the Fas ┬ľassociated death domain (FADD) to the receptors, which initiates binding of procaspase-8 and procaspase-9, and the formation of the death inducing signaling complex (DISC) [9].
TRAIL Binding (Binding) of DR5 associated with death
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.60 Pain Relevance 0.03
TRAIL initiates apoptosis by binding to two death receptors, DR4 and DR5, while binding to the decoy receptors which lack the death domain, such as DCR1, DCR2 and osteoprotegerin, inhibits its pro-apoptotic activity [9].
TRAIL Binding (binding) of DR5 associated with apoptosis and death
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.69 Pain Relevance 0.07

General Comments

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