INT194596

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 6.00
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (HLA-DRB4, TNFSF10) endosome (HLA-DRB4) extracellular space (TNFSF10)
extracellular region (TNFSF10) Golgi apparatus (HLA-DRB4) endoplasmic reticulum (HLA-DRB4)
HLA-DRB4 (Homo sapiens)
TNFSF10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 20 92.44 High High
rheumatoid arthritis 18 89.72 High High
Inflammation 64 78.08 Quite High
antagonist 2 75.72 Quite High
cva 1 53.76 Quite High
cINOD 2 47.08 Quite Low
Pain 1 29.28 Quite Low
Kinase C 10 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 298 100.00 Very High Very High Very High
Death 43 100.00 Very High Very High Very High
Cancer 261 93.56 High High
Necrosis 7 91.00 High High
Rheumatoid Arthritis 18 89.72 High High
Colon Cancer 88 83.48 Quite High
Diabetes Mellitus 83 81.96 Quite High
Solid Tumor 2 79.92 Quite High
Toxicity 8 79.12 Quite High
INFLAMMATION 60 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRAIL initiates apoptosis by binding to two death receptors, DR4 and DR5, while binding to the decoy receptors which lack the death domain, such as DCR1, DCR2 and osteoprotegerin, inhibits its pro-apoptotic activity [9].
DR4 Binding (binding) of TRAIL associated with apoptosis and death
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.68 Pain Relevance 0.07
TRAIL induces apoptosis by binding and cross-linking the death-domain containing receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) [3].
DR4 Binding (binding) of TRAIL associated with apoptosis and death
2) Confidence 0.08 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.09 Pain Relevance 0.16
Binding of TRAIL to the death inducing receptors DR4/DR5 results in the recruitment of the Fas ┬ľassociated death domain (FADD) to the receptors, which initiates binding of procaspase-8 and procaspase-9, and the formation of the death inducing signaling complex (DISC) [9].
DR4 Binding (Binding) of TRAIL associated with death
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.60 Pain Relevance 0.03
When TRAIL binds TRAIL-R1 (DR4) and TRAIL-R2 (DR5) apoptotic signals are transduced.
DR4 Binding (binds) of TRAIL associated with apoptosis
4) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.62 Pain Relevance 0.11

General Comments

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