INT194618

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.94
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a, IL8) extracellular region (Il17a, IL8) signal transduction (IL8)
intracellular (IL8)
Anatomy Link Frequency
fibroblast 2
eosinophils 2
Il17a (Mus musculus)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 37 95.40 Very High Very High Very High
cytokine 67 90.72 High High
rheumatoid arthritis 25 74.08 Quite High
Arthritis 4 47.52 Quite Low
Infliximab 17 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 104 97.16 Very High Very High Very High
INFLAMMATION 38 95.40 Very High Very High Very High
Rhinitis 3 90.88 High High
Eczema 1 82.64 Quite High
Rheumatoid Arthritis 25 74.08 Quite High
Disease 21 57.52 Quite High
Necrosis 5 54.24 Quite High
Cancer 5 53.88 Quite High
Arthritis 4 47.52 Quite Low
Bacterial Respiratory Disease 2 38.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors demonstrated that IL-23 in combination with IL-17A and IL-17F promoted the production of CXCL1 and IL-8 in human eosinophils generating a strong neutrophilotactic signal, whereas IL-23 together with IL-17F alone induced the production of IL-1?
IL-17A Positive_regulation (promoted) of Gene_expression (production) of IL-8 in eosinophils
1) Confidence 0.01 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.81 Pain Relevance 0.05
and IL-17, which in turn stimulate the further production of IL-15, IL-8 and IL-6 in fibroblast-like synoviocytes [7,8].
IL-17 Positive_regulation (stimulate) of Gene_expression (production) of IL-8 in fibroblast
2) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 1.13 Pain Relevance 0.63

General Comments

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