INT194619

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.23
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il15, TNF) extracellular region (Il15, TNF) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
synovium 2
Il15 (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 44 100.00 Very High Very High Very High
Inflammation 22 100.00 Very High Very High Very High
rheumatoid arthritis 50 86.80 High High
Arthritis 6 41.12 Quite Low
Infliximab 34 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
abatacept 2 5.00 Very Low Very Low Very Low
Etanercept 2 5.00 Very Low Very Low Very Low
Adalimumab 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 100.00 Very High Very High Very High
Rheumatoid Arthritis 50 86.80 High High
Disease 14 70.24 Quite High
Necrosis 8 66.96 Quite High
Cancer 8 66.60 Quite High
Arthritis 6 41.12 Quite Low
Frailty 2 5.00 Very Low Very Low Very Low
Synovitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-15 may also contribute to an increased production of the pro-inflammatory cytokines TNF, IFN-?
IL-15 Spec (may) Positive_regulation (contribute) of Gene_expression (production) of TNF associated with inflammation and cytokine
1) Confidence 0.24 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 1.09 Pain Relevance 0.57
Taken together, these findings suggest that an IL-15-dependent pro-inflammatory feedback loop may be created in the inflamed synovium, in which IL-15 stimulates the production of TNF, IFN-?
IL-15 Positive_regulation (stimulates) of Gene_expression (production) of TNF in synovium associated with inflammation
2) Confidence 0.24 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 1.14 Pain Relevance 0.63

General Comments

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