INT194621

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
natural killer cell 1
T cells 1
TNF (Homo sapiens)
Klrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 11 95.88 Very High Very High Very High
rheumatoid arthritis 25 95.24 Very High Very High Very High
cytokine 22 76.96 Quite High
Infliximab 17 11.96 Low Low
Etanercept 1 9.68 Low Low
Adalimumab 1 8.72 Low Low
abatacept 1 7.76 Low Low
Arthritis 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 95.88 Very High Very High Very High
Rheumatoid Arthritis 25 95.24 Very High Very High Very High
Necrosis 4 50.00 Quite Low
Cancer 4 50.00 Quite Low
Disease 7 35.60 Quite Low
Arthritis 3 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low
Synovitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This notion is supported by a report in which either TNF or IL-15 could induce the expression of natural killer cell receptor NKG2D on auto-reactive CD4+CD28- T cells [22], and that these cells may contribute to the self-perpetuating inflammation in RA.
TNF Positive_regulation (induce) of in natural killer cell Gene_expression (expression) of NKG2D in T cells associated with inflammation and rheumatoid arthritis
1) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526582 Disease Relevance 0.50 Pain Relevance 0.32

General Comments

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