INT194629

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.67
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pik3cb) signal transduction (Pik3cb) cell adhesion (Pik3cb)
nucleus (Pik3cb) cytoplasm (Pik3cb)
Pik3cb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 52 99.98 Very High Very High Very High
antagonist 12 68.80 Quite High
Kinase C 1 55.76 Quite High
Inflammation 52 50.00 Quite Low
agonist 12 26.08 Quite Low
adenocard 36 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 54 99.98 Very High Very High Very High
Infection 10 83.96 Quite High
Adenovirus Infection 7 50.32 Quite High
INFLAMMATION 59 50.00 Quite Low
Apoptosis 23 41.36 Quite Low
Hyperplasia 4 19.40 Low Low
Disease 16 17.60 Low Low
Cancer 21 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PI3K gene was successfully knocked down in MSCs by transfection with PI3K siRNA as compared to scrambled siRNA (Sc siRNA) transfected cells which was indicated by abrogation of pAkt expression (Figure S2).
Positive_regulation (transfection) of Gene_expression (transfection) of PI3K
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0 Pain Relevance 0
Induction of AIA induced upregulation in the expression level of various key signaling proteins such as PI3K, PKB/Akt (total and phosphorylated) and TNF-?
Positive_regulation (induced) of Gene_expression (expression) of PI3K associated with arthritis
2) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.27 Pain Relevance 0.17
Induction of AIA induced upregulation in the expression level of various key signaling proteins such as PI3K, PKB/Akt (total and phosphorylated) and TNF-?
Positive_regulation (upregulation) of Gene_expression (expression) of PI3K associated with arthritis
3) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.27 Pain Relevance 0.17
Expression of genes associated with the PI3K, PKC and nuclear factor kappa B (NFKB) pathways were induced with respect to those found in saline treated animals on average by a factor of 3.8, 4 and 4.6 respectively by each of the viruses included in this study.
Positive_regulation (induced) of Gene_expression (Expression) of PI3K
4) Confidence 0.14 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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