INT194633

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Context Info
Confidence 0.21
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.83
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pik3cb) signal transduction (Pik3cb) cell adhesion (Pik3cb)
nucleus (Pik3cb) cytoplasm (Pik3cb)
Anatomy Link Frequency
DLN 2
Pik3cb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 52 92.84 High High
Inflammation 50 92.24 High High
Paracetamol 60 86.92 High High
agonist 12 84.68 Quite High
antagonist 12 82.12 Quite High
rheumatoid arthritis 10 72.40 Quite High
Osteoarthritis 2 67.84 Quite High
adenocard 36 66.60 Quite High
cytokine 7 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 20 97.92 Very High Very High Very High
Necrosis 6 97.44 Very High Very High Very High
Apoptosis 32 93.28 High High
Arthritis 54 92.84 High High
INFLAMMATION 54 92.24 High High
Aging 38 83.64 Quite High
Disease 16 79.76 Quite High
Colon Cancer 6 73.20 Quite High
Rheumatoid Arthritis 10 72.40 Quite High
Osteoarthritis 2 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paradoxically, these increases in Akt phosphorylation were associated with diminished mammalian target of rapamycin (mTOR) phosphorylation, along with decreased levels of insulin receptor beta (IR-?)
Negative_regulation (decreased) of Gene_expression (levels) of PI3K
1) Confidence 0.21 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.30 Pain Relevance 0.21
The expression levels of PI3K, PKB/Akt, IKK?
Negative_regulation (levels) of Gene_expression (expression) of PI3K
2) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.52 Pain Relevance 0.10
Analysis of synovia and DLN protein extracts revealed a decreased expression level of PI3K, PKB/Akt, IKK, NF-?
Negative_regulation (level) of Gene_expression (expression) of PI3K in DLN
3) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526584 Disease Relevance 1.01 Pain Relevance 0.48

General Comments

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