INT194643

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.40
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 15 91.52 High High
Infliximab 1 83.32 Quite High
antagonist 1 71.60 Quite High
psoriasis 1 59.24 Quite High
Crohn's disease 1 58.80 Quite High
rheumatoid arthritis 3 58.12 Quite High
cytokine 24 50.00 Quite Low
cINOD 3 24.56 Low Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 29 99.44 Very High Very High Very High
Apoptosis 89 97.52 Very High Very High Very High
Systemic Lupus Erythematosus 52 92.64 High High
INFLAMMATION 19 91.52 High High
Disease 24 90.48 High High
Psoriasis 1 59.24 Quite High
Rheumatoid Arthritis 3 58.12 Quite High
Autoimmune Disease 3 30.88 Quite Low
Cancer 5 11.12 Low Low
Necrosis 5 10.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the therapeutical relevance of these results, new studies need to be designed to evaluate the use of these drugs as TNF?
Positive_regulation (evaluate) of Regulation (use) of TNF
1) Confidence 0.28 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.89 Pain Relevance 0.21
Doubling the concentration of p38 and JNK inhibitors did not significantly increase their inhibitory effect on TNF-?
Neg (not) Positive_regulation (increase) of Regulation (effect) of TNF
2) Confidence 0.03 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838737 Disease Relevance 1.51 Pain Relevance 0

General Comments

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