INT194644

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.42
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, TNF) plasma membrane (Tlr4, TNF) intracellular (Tlr4, TNF)
extracellular space (TNF) extracellular region (TNF) extracellular matrix organization (TNF)
Tlr4 (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 114 95.84 Very High Very High Very High
cytokine 83 94.36 High High
Inflammatory response 14 92.80 High High
Inflammatory mediators 3 66.00 Quite High
rheumatoid arthritis 3 33.96 Quite Low
corticosteroid 8 19.56 Low Low
chemokine 8 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Premature Birth 51 98.52 Very High Very High Very High
INFLAMMATION 109 95.84 Very High Very High Very High
Pneumonia 33 95.52 Very High Very High Very High
Alzheimer's Dementia 1 93.52 High High
Bacterial Respiratory Disease 1 85.84 High High
Sprains And Strains 1 83.80 Quite High
Death 1 77.72 Quite High
Shock 4 76.68 Quite High
Systemic Lupus Erythematosus 52 76.48 Quite High
Disease 23 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS significantly increased MIP-2 (5.5-fold and 7.9-fold, respectively; P < 0.05) and TNF?
LPS Positive_regulation (increased) of TNF
1) Confidence 0.58 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2873469 Disease Relevance 0.14 Pain Relevance 0.19
Both LPS and PAM3 significantly increased MIP-2 and TNF?
LPS Positive_regulation (increased) of TNF
2) Confidence 0.45 Published 2010 Journal BMC Pulm Med Section Abstract Doc Link PMC2873469 Disease Relevance 0.14 Pain Relevance 0.07
Our lab has demonstrated that LPS and E. coli cause increased uNK cell cytotoxicity and TNF-?
LPS Positive_regulation (cause) of TNF
3) Confidence 0.31 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 0.83 Pain Relevance 0
Moreover, CD14 does not facilitate local release of TNF induced by intrapulmonary R-LPS at any dose tested.


LPS Neg (not) Positive_regulation (induced) of TNF
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.39 Pain Relevance 0.19
LPS-induced elevations of serum TNF, IL-1, and IL-6 levels were also less in germfree mice [11, 12].
LPS Positive_regulation (elevations) of TNF
5) Confidence 0.06 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.64 Pain Relevance 0.30
inhibition [4-7] are not yet entirely known, it has been reported that chloroquine inhibited LPS-induced TNF?
LPS Positive_regulation (induced) of TNF
6) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.27 Pain Relevance 0

General Comments

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