INT194645

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.27 Pain Relevance 0

signal transduction (Tlr4, TNF) plasma membrane (Tlr4, TNF) intracellular (Tlr4, TNF) extracellular space (TNF) extracellular region (TNF) extracellular matrix organization (TNF)

Tlr4 (Mus musculus) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 24 50.00 Inflammation 12 42.96 rheumatoid arthritis 3 34.36 corticosteroid 8 19.96 Arthritis 3 5.00 cINOD 2 5.00 Inflammatory response 2 5.00 psoriasis 1 5.00 Crohn's disease 1 5.00 Infliximab 1 5.00

Disease Link Frequency Relevance Heat Systemic Lupus Erythematosus 52 76.48 Disease 23 76.00 INFLAMMATION 15 42.96 Rheumatoid Arthritis 3 34.36 Malaria 1 21.12 Serositis 4 5.00 Hematological Disease 3 5.00 Arthritis 3 5.00 Mouth Ulcer 3 5.00 Sunburn 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

inhibition [4-7] are not yet entirely known, it has been reported that chloroquine inhibited LPS-induced TNF?

Negative_regulation (inhibited) of LPS Positive_regulation (induced) of TNF

1) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.27 Pain Relevance 0

General Comments

This test has worked.