INT194646

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.69
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD28, CD86) cytosol (CD28) cell-cell signaling (CD86)
Anatomy Link Frequency
CD86 3
T cell 3
joint 1
CD28 (Homo sapiens)
CD86 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 270 96.96 Very High Very High Very High
cytokine 48 96.80 Very High Very High Very High
Inflammation 111 96.40 Very High Very High Very High
psoriasis 6 90.60 High High
rheumatoid arthritis 145 83.68 Quite High
Arthritis 67 75.16 Quite High
metalloproteinase 3 74.68 Quite High
methotrexate 63 68.16 Quite High
ischemia 1 64.00 Quite High
chemokine 54 63.92 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 3 97.68 Very High Very High Very High
INFLAMMATION 113 96.40 Very High Very High Very High
Psoriasis 6 90.60 High High
Graft Vs Host Disease 2 89.12 High High
Organ Transplantation 6 88.04 High High
Rheumatoid Arthritis 147 83.68 Quite High
Adhesions 7 77.52 Quite High
Synovitis 6 75.60 Quite High
Juvenile Chronic Polyarthritis 40 75.16 Quite High
Disease 85 67.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CTLA-4 binds to CD80 and CD86 with higher avidity than CD28, thus preventing co-stimulation through this pathway, and is a major down-regulatory signal for T cells.
CD28 Binding (binds) of CD86 in CD86
1) Confidence 0.40 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2569144 Disease Relevance 0.52 Pain Relevance 0.51
The second, or co-stimulatory, signal is delivered following the engagement of CD80/CD86 on antigen-presenting cells with a cognate receptor, CD28, on the surface of the T cell [6,7].
CD28 Binding (engagement) of CD86 in T cell
2) Confidence 0.37 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906816 Disease Relevance 0.29 Pain Relevance 0.76
The costimulation signal is delivered when B7-1/CD80 and B7-2/CD86 on the surface of DCs engage CD28 on T-cells (Bromley et al 2001).
CD28 Binding (engage) of CD86 in T-cells
3) Confidence 0.19 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.06 Pain Relevance 0
It competes with CD28 for binding to CD80/CD86 with a much higher affinity for these ligands, and provides a negative feedback loop (Sfikakis & Via 1997).
CD28 Binding (binding) of CD86 in CD86
4) Confidence 0.11 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012435 Disease Relevance 0.31 Pain Relevance 0.30
It can bind both CD80 and CD86 with higher affinity than CD28.
CD28 Binding (bind) of CD86 in CD86
5) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.86 Pain Relevance 0.31
The expression of CD28 in the CCL5+ cells may be due to a selective recruitment of activated memory cells that are still expressing CD28, or possibly due to re-expression of CD28 in the joint in the presence of high numbers of cells expressing CD28 ligands such as CD80 or CD86 [48].
CD28 Binding (ligands) of CD86 in joint
6) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.28 Pain Relevance 0.17
One of the best studied co stimulatory pathways is the interaction between the T cell receptor CD28 with CD80 (B 7-1) and CD86 (B 7-2) on the APC.
CD28 Binding (interaction) of CD86 in T cell
7) Confidence 0.03 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.38 Pain Relevance 0.16

General Comments

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