INT194647

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 4.90
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD28, CD80) cytosol (CD28) intracellular (CD80)
cell-cell signaling (CD80)
Anatomy Link Frequency
T-cells 10
CD86 3
joint 1
plaque 1
CD28 (Homo sapiens)
CD80 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 404 96.96 Very High Very High Very High
cytokine 147 96.80 Very High Very High Very High
Inflammation 144 96.40 Very High Very High Very High
psoriasis 145 92.88 High High
rheumatoid arthritis 212 90.56 High High
tolerance 40 78.88 Quite High
Arthritis 79 75.16 Quite High
metalloproteinase 3 74.68 Quite High
methotrexate 92 74.08 Quite High
ischemia 2 64.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 17 97.68 Very High Very High Very High
INFLAMMATION 149 96.40 Very High Very High Very High
Psoriasis 161 92.88 High High
Rheumatoid Arthritis 216 90.56 High High
Graft Vs Host Disease 8 89.12 High High
Cancer 255 88.92 High High
Organ Transplantation 12 88.04 High High
Skin Cancer 114 87.08 High High
Adhesions 22 77.52 Quite High
Renal Cancer 5 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CTLA-4 binds to CD80 and CD86 with higher avidity than CD28, thus preventing co-stimulation through this pathway, and is a major down-regulatory signal for T cells.
CD28 Binding (binds) of CD80 in CD86
1) Confidence 0.40 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2569144 Disease Relevance 0.52 Pain Relevance 0.51
The second, or co-stimulatory, signal is delivered following the engagement of CD80/CD86 on antigen-presenting cells with a cognate receptor, CD28, on the surface of the T cell [6,7].
CD28 Binding (engagement) of CD80 in T cell
2) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906816 Disease Relevance 0.29 Pain Relevance 0.76
The costimulation signal is delivered when B7-1/CD80 and B7-2/CD86 on the surface of DCs engage CD28 on T-cells (Bromley et al 2001).
CD28 Binding (engage) of B7 in T-cells
3) Confidence 0.20 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.06 Pain Relevance 0
The costimulation signal is delivered when B7-1/CD80 and B7-2/CD86 on the surface of DCs engage CD28 on T-cells (Bromley et al 2001).
CD28 Binding (engage) of B7 in T-cells
4) Confidence 0.20 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.06 Pain Relevance 0
The costimulation signal is delivered when B7-1/CD80 and B7-2/CD86 on the surface of DCs engage CD28 on T-cells (Bromley et al 2001).
CD28 Binding (engage) of CD80 in T-cells
5) Confidence 0.20 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.06 Pain Relevance 0
Ligation of CD28 by CD80/86 is required for clonal expansion of naïve CD4 T cells.
CD28 Binding (Ligation) of CD80 in T cells
6) Confidence 0.15 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998809 Disease Relevance 0.06 Pain Relevance 0.03
It can bind both CD80 and CD86 with higher affinity than CD28.
CD28 Binding (bind) of CD80 in CD86
7) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.86 Pain Relevance 0.31
It competes with CD28 for binding to CD80/CD86 with a much higher affinity for these ligands, and provides a negative feedback loop (Sfikakis & Via 1997).
CD28 Binding (binding) of CD80 in CD86
8) Confidence 0.09 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012435 Disease Relevance 0.31 Pain Relevance 0.30
One of these signals is induced by the interaction of CD80/86 on antigen-presenting cells (APCs) and CD28 on T cells.
CD28 Binding (interaction) of CD80 in T cells
9) Confidence 0.09 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012435 Disease Relevance 0.35 Pain Relevance 0.33
On the surface of activated T cells, CTLA4 (CD152 and CD28) is up-regulated and may then interact with CD80, leading to deactivation of the T cell.
CD28 Binding (interact) of CD80 in T cell
10) Confidence 0.06 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.23 Pain Relevance 0.23
IDEC-114 blocks the CD28/CD80 co-stimulatory interaction which is an activation signal without affecting the CTLA4/CD80 interaction which is the deactivation signal.[2728] In a phase I open label study, 24 patients with severe plaque psoriasis received one single IV infusion of 0.05, 1, 5, 10, or 15 mg/kg IDEC-114.
CD28 Binding (interaction) of CD80 in plaque associated with psoriasis
11) Confidence 0.06 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.24 Pain Relevance 0.23
The expression of CD28 in the CCL5+ cells may be due to a selective recruitment of activated memory cells that are still expressing CD28, or possibly due to re-expression of CD28 in the joint in the presence of high numbers of cells expressing CD28 ligands such as CD80 or CD86 [48].
CD28 Binding (ligands) of CD80 in joint
12) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.28 Pain Relevance 0.17
CTLA4 competetively inhibits binding of CD28 to CD80 and 86.
CD28 Binding (binding) of CD80
13) Confidence 0.02 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.28 Pain Relevance 0.11
One of the best studied co stimulatory pathways is the interaction between the T cell receptor CD28 with CD80 (B 7-1) and CD86 (B 7-2) on the APC.
CD28 Binding (interaction) of CD80 in T cell
14) Confidence 0.02 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.38 Pain Relevance 0.16
The T-cell surface protein, CTLA4, competes with CD28 for B7, and binding of CTLA4 to B7 inhibits T-cell proliferation and the elaboration of immune stimulatory cytokines.
CD28 Binding (competes) of B7 in T-cell associated with cytokine
15) Confidence 0.02 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004577 Disease Relevance 0.36 Pain Relevance 0.09
An example is CTLA-4, a negative regulator of T-cell activation, which is expressed on the T-cells and, like its homolog CD28, binds to B7 on the surface of the APC.
CD28 Binding (binds) of B7 in T-cells
16) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.58 Pain Relevance 0

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