INT194657

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.30
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCR2) plasma membrane (CCR2) cytoplasm (CCR2)
signal transducer activity (CCR2)
CCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 50 99.16 Very High Very High Very High
Inflammation 66 96.96 Very High Very High Very High
chemokine 60 95.52 Very High Very High Very High
rheumatoid arthritis 10 89.76 High High
antagonist 2 87.00 High High
cytokine 2 71.08 Quite High
methotrexate 14 5.00 Very Low Very Low Very Low
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 10 99.16 Very High Very High Very High
Pancreatic Cancer 5 98.64 Very High Very High Very High
INFLAMMATION 65 96.96 Very High Very High Very High
Skin Cancer 2 94.00 High High
Disease 15 93.44 High High
Rheumatoid Arthritis 10 89.76 High High
Peritonitis 1 84.72 Quite High
Adenocarcinoma 90 75.24 Quite High
Breast Cancer 4 71.76 Quite High
Hepatitis C Virus Infection 2 58.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For PDCs, CCR2 was significantly decreased, whereas the MDCs were unaffected.
Negative_regulation (decreased) of CCR2
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.98 Pain Relevance 0.20
Blockade of CCR2 in collagen-induced arthritis produced varying results, with the effect being critically dependent on the timing of blockade, suggesting that in the late phase of disease, other populations of cells, perhaps with a regulatory function, may express CCR2 [31].
Negative_regulation (Blockade) of CCR2 associated with disease and arthritis
2) Confidence 0.18 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 1.32 Pain Relevance 0.87

General Comments

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