INT19466

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Context Info
Confidence 0.52
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.39
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Clcn1) transmembrane transport (Clcn1)
Anatomy Link Frequency
skeletal muscle 1
Clcn1 (Mus musculus)
Pain Link Frequency Relevance Heat
noradrenaline 7 100.00 Very High Very High Very High
Pain 2 99.78 Very High Very High Very High
Clonidine 3 99.50 Very High Very High Very High
anesthesia 1 99.16 Very High Very High Very High
epidural 1 98.94 Very High Very High Very High
Spinal cord 5 86.60 High High
adenocard 1 74.44 Quite High
Rsd 6 71.84 Quite High
imagery 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 5 100.00 Very High Very High Very High
Autonomic Dysreflexia 4 100.00 Very High Very High Very High
Pain 2 99.78 Very High Very High Very High
Hypopituitarism 10 98.12 Very High Very High Very High
Hypertrophy 1 96.72 Very High Very High Very High
Myotonia 7 95.76 Very High Very High Very High
Pheochromocytoma 9 90.24 High High
Frailty 16 89.36 High High
Shock 2 81.84 Quite High
Toxicity 8 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mis-splicing and expression loss of CLCN1 protein in skeletal muscle is associated with myotonia in DM1 patients and mouse models [28, 29].
Negative_regulation (loss) of CLCN1 in skeletal muscle associated with hypopituitarism
1) Confidence 0.52 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.25 Pain Relevance 0
Pain was not a feature of dominant CLCN1 mutations while it could be seen in the others, more frequently in SCN4A mutations.
Negative_regulation (feature) of CLCN1 associated with pain
2) Confidence 0.39 Published 2009 Journal Neuromuscul. Disord. Section Abstract Doc Link 18337100 Disease Relevance 0.72 Pain Relevance 0.10
It has been noted by others [33] that ADR cardiotoxicity can be reduced by conjugation of ADR to the peptides D-penetratin and SynB1.
Negative_regulation (reduced) of ADR associated with cardiovascular disorder under development
3) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.53 Pain Relevance 0
Epidural anesthesia should be administered early in labor to prevent ADR.
Negative_regulation (prevent) of ADR associated with autonomic dysreflexia, anesthesia and epidural
4) Confidence 0.12 Published 2003 Journal Obstet Gynecol Surv Section Abstract Doc Link 14515065 Disease Relevance 0.76 Pain Relevance 0.30
Clonidine resulted in significant suppression of both noradrenaline (NA) and adrenaline (ADR) in essential hypertensives (EHT) without any false positive findings.
Negative_regulation (suppression) of ADR associated with noradrenaline and clonidine
5) Confidence 0.12 Published 1991 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2065469 Disease Relevance 0.71 Pain Relevance 0.56
However, the absence of adr activity specifically enhanced RNAi-dependent co-suppression.
Negative_regulation (absence) of adr
6) Confidence 0.03 Published 2006 Journal Journal of RNAi and Gene Silencing : An International Journal of RNA and Gene Targeting Research Section Body Doc Link PMC2737212 Disease Relevance 0.41 Pain Relevance 0.25

General Comments

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