INT194661

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.07
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL5) aging (CCL5) extracellular region (CCL5)
cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
T-cell 2
synovium 1
neutrophils 1
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 288 100.00 Very High Very High Very High
Inflammation 252 100.00 Very High Very High Very High
cytokine 92 95.84 Very High Very High Very High
Kinase C 2 92.48 High High
Arthritis 250 91.04 High High
methotrexate 70 90.44 High High
COX-2 inhibitor 23 74.00 Quite High
rheumatoid arthritis 45 61.44 Quite High
adenocard 4 45.20 Quite Low
cINOD 9 28.60 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 253 100.00 Very High Very High Very High
Osteomyelitis 22 95.12 Very High Very High Very High
Herpes Simplex Virus 238 91.60 High High
Juvenile Chronic Polyarthritis 200 91.04 High High
Disseminated Intravascular Coagulation 74 88.16 High High
Coagulation Disorder 12 87.36 High High
Malignant Neoplastic Disease 19 83.92 Quite High
Cancer 36 82.56 Quite High
Lymphatic System Cancer 26 82.32 Quite High
Infection 115 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, it is known that CCL5 is readily bound by glycosominoglycans and extracellular matrix, which are abundant in inflamed synovium [49].
CCL5 Binding (bound) of in synovium
1) Confidence 0.46 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.63 Pain Relevance 0.34
Levels of mRNA of the three inflammatory chemokines CCL5 (RANTES), CCL3 (MIP-1?)
RANTES Binding (mRNA) of associated with chemokine and inflammation
2) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.69 Pain Relevance 0.43
Levels of mRNA of the three inflammatory chemokines CCL5 (RANTES), CCL3 (MIP-1?)
RANTES Binding (three) of associated with chemokine and inflammation
3) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.69 Pain Relevance 0.43
Levels of mRNA of the three inflammatory chemokines CCL5 (RANTES), CCL3 (MIP-1?)
CCL5 Binding (mRNA) of associated with chemokine and inflammation
4) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.69 Pain Relevance 0.43
Levels of mRNA of the three inflammatory chemokines CCL5 (RANTES), CCL3 (MIP-1?)
CCL5 Binding (three) of associated with chemokine and inflammation
5) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.69 Pain Relevance 0.43
RS cells secrete interleukin-8 (IL-8) which serves as a chemoattractant for neutrophils, and express multiple chemokine ligands including CCL5, CCL17 and CCL22, which attract certain T-cell subsets [9].
CCL5 Binding (ligands) of in neutrophils associated with chemokine
6) Confidence 0.15 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2907869 Disease Relevance 1.08 Pain Relevance 0.12
, GM-CSF, RANTES, and SDF-1, normalized to the expression of endogenous HPRT and tubulin genes.
RANTES Binding (normalized) of
7) Confidence 0.06 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.73 Pain Relevance 0.25
Antithrombin enhances Tyr416 and inhibits Tyr527 phosphorylation of src tyrosine kinases; in combination with the chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted); however, it weakens the RANTES-enhanced phosphorylation of Tyr416 [69].
RANTES Binding (weakens) of in T-cell associated with chemokine
8) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.43 Pain Relevance 0.16
Antithrombin enhances Tyr416 and inhibits Tyr527 phosphorylation of src tyrosine kinases; in combination with the chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted); however, it weakens the RANTES-enhanced phosphorylation of Tyr416 [69].
RANTES Binding (combination) of in T-cell associated with chemokine
9) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.45 Pain Relevance 0.13

General Comments

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