INT194676

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

response to stress (MAPK1, IL10) nucleoplasm (MAPK1) mitochondrion (MAPK1)
DNA binding (MAPK1) microtubule organizing center (MAPK1) extracellular space (IL10)
Anatomy Link Frequency
T cells 6
MAPK1 (Homo sapiens)
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 60 94.80 High High
cytokine 68 93.76 High High
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 62 94.80 High High
Asthma 6 83.08 Quite High
Autoimmune Disease 28 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Hypersensitivity 14 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Sepsis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In human CD4 T cells as well as in anergic murine T cells, inhibition of p38 MAPK resulted in diminished production of IL-10 [60,63,64].
Negative_regulation (inhibition) of p38 MAPK in T cells Negative_regulation (diminished) of Gene_expression (production) of IL-10 in T cells
1) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.17 Pain Relevance 0.27
In murine and human T cells, inhibition of p38 MAPK by SB203580 or a dominant-negative mutant of p38 MAPK strongly diminished IL-10 expression [60,63,64,67].
Negative_regulation (inhibition) of p38 MAPK in T cells Negative_regulation (diminished) of Gene_expression (expression) of IL-10 in T cells
2) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.17 Pain Relevance 0.23

General Comments

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