INT194685

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.18
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

response to stress (MAPK1, IL10) nucleoplasm (MAPK1) mitochondrion (MAPK1)
DNA binding (MAPK1) microtubule organizing center (MAPK1) extracellular space (IL10)
Anatomy Link Frequency
monocytes 2
Th2 cell 2
T cells 2
MAPK1 (Homo sapiens)
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 90 97.08 Very High Very High Very High
rheumatoid arthritis 12 93.68 High High
cytokine 102 93.08 High High
Inflammatory response 3 90.00 High High
Central nervous system 3 88.68 High High
Arthritis 9 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 30 97.44 Very High Very High Very High
INFLAMMATION 93 97.08 Very High Very High Very High
Rheumatoid Arthritis 12 93.68 High High
Asthma 9 86.44 High High
Autoimmune Disease 42 80.48 Quite High
Thymoma 3 48.64 Quite Low
Hypersensitivity 21 47.32 Quite Low
Apoptosis 3 36.08 Quite Low
Heart Rate Under Development 6 32.12 Quite Low
Eosinophilia 3 9.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Early studies indicated that p38 MAPK regulates IL-10 expression in monocytes [69].
p38 MAPK Regulation (regulates) of Gene_expression (expression) of IL-10 in monocytes
1) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.16 Pain Relevance 0.22
Whether p38 MAPK controls IL-10 expression through Sp1 in T cells remains to be shown.
p38 MAPK Spec (Whether) Regulation (controls) of Gene_expression (expression) of IL-10 in T cells
2) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.09
However, in view of recent advances underlining the essential role of p38 MAPK in IL-10 expression and in Th2 cell functions and of the regulatory capacities of IL-10 and Th2 cells in Th1-driven inflammation, p38 MAPK inhibitors might be associated with some unwanted effects on the immune system, enhancing rather than ameliorating the underlying inflammatory response in Th1-driven diseases.
p38 MAPK Regulation (role) of Gene_expression (expression) of IL-10 in Th2 cell associated with inflammatory response, inflammation and disease
3) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 1.02 Pain Relevance 0.38

General Comments

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