INT194700

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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.55
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CD28, MAPK1) nucleoplasm (MAPK1) mitochondrion (MAPK1)
Golgi apparatus (MAPK1) DNA binding (MAPK1) protein complex (MAPK1)
Anatomy Link Frequency
hepatocyte 1
CD28 (Homo sapiens)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 68 88.92 High High
Inflammation 60 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 4 78.56 Quite High
Stress 12 77.68 Quite High
INFLAMMATION 62 5.00 Very Low Very Low Very Low
Autoimmune Disease 28 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Hypersensitivity 14 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Asthma 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, ligation of CD30, CD28, or EphB6 also activates p38 MAPK in the absence of TCR ligation [46,47,49,51].
CD28 Positive_regulation (activates) of p38 MAPK
1) Confidence 0.10 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.26 Pain Relevance 0.08
The co-stimulatory molecules CD28, 4-1BB, CD26, CD30, inducible co-stimulator (ICOS), and erythropoietin-producing hepatocyte B6 (EphB6) have been shown to activate p38 MAPK synergistically with TCR stimulation [44-50].
CD28 Positive_regulation (activate) of p38 MAPK in hepatocyte
2) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.29 Pain Relevance 0.09

General Comments

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